Global ETD Search
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Showing 1 to 7 of 7 for “"Mitragynine"”.
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Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
… the structure of the major alkaloid, mitragynine, two classes of compounds were designed and synthesized: phenylpiperidines, including phenylaminopiperidines and phenylamidopiperidines, and tetrahydro-beta-carbolines. They were further submitted to in vitro evaluation on mu, delta and …
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Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
… mechanisms of a novel, plant-derived alkaloid mitragynine (MG), a constituent of the kratom plant (Mitragyna speciosa) in a mouse model of CIPN. Kratom products have emerged in the US in recent years as a popular form of self-treating pain, opioid withdrawal, and symptoms of anxiety and …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… and Cannabigerol from Cannabis Sativa along with Mitragynine from Mitragyna Speciosa. Not only did they show reduction in mechanical allodynia, but Mitragynine studies showed promise in female-only models. In the present set of experiments, we conduct dose-response studies using both single agents …
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
… CM304 (sigma-1 receptor antagonist), mitragynine and 7-hydroxymitragynine (μ-opioid receptor agonists), for the treatment of drug abuse. The affinity of cocaine to sigma-1 receptors render the hypothesis that targeting sigma-1 receptors using antagonists will be an effective strategy …
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Evaluating preference-seeking and aversive qualities of Salvia divinorumand Mitragyna speciosa
… states. As expected, rats shoplace preference to mitragynine similar to that of 1mg/kg (+)-Amphetamine. This effect was much less pronounced with the extract and its fractions. Rats shorobust place aversion to both Salvia divinorum and salvinorin A. These findings suggest that products that …
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Radical Approaches to Alangium and Mitragyna Alkaloids
… synthesis of a structurally simpler analogue of mitragynine (p).