Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Single-agents"”.
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Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential
… evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… and bicyclic pyrimidine-base heterocycles as single agents with combination chemotherapy potential having both antiangiogenic effects and cytotoxic effects. This dissertation also describes selective tumor targeting with 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines analogs with heteroatom …
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Design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential or as inhibitors of tubulin or thymidylate synthase
… research progress in the areas of multitargeted single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis.</p><p> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate …
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The effect of potential anticancer gene products on breast cancer cell lines
… therapeutics typically has been investigated as single agents. More recently combinatorial agents have been investigated for which some combinations have shown synergism. The present study was designed to evaluate three different potential anticancer factors, decorin, interferon beta (IFNb), and …
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Design and Synthesis of Pyrimidine Based Heterocycles as Potential Anti-cancer Agents with Combination Chemotherapeutic Potential or Targeted One Carbon Metabolism Inhibition and Anti-opportunistic Agents
… tricyclic pyrimidine-based heterocycles as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective <em>Pneumocystis jirovecii </em>(pj)<em> …
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… cancer chemotherapy. Microtubule targeting agents (MTAs) are a structurally diverse set of compounds that disrupt microtubule dynamics and exert their anticancer effect. Among the various classes of such agents, the colchicine site binding agents are particularly important as they circumvent …
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… we conduct dose-response studies using both single agents and combinations of these plant alkaloids. These studies were designed to fully evaluate the extent to which these compounds can alleviate mechanical allodynia in a chemotherapy-induced, female-only mouse model. To further emphasize …
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The Symptom Experience of Patients Receiving Epidermal Growth Factor Receptor Inhibitors
… tumors, and may be first, second or third-line agents which can be used as single agents or in combination with other therapies. The most common side effect of these agents include dermatologic effects, such as rashes, hair, and nail changes, but they can also contribute to other side effects …
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Synergic Effect on Cell Death by Co-treatment with TRAIL and Human Anti-DR5 Antibody
… cells. In previous study we isolated a human single-chain variable fragment (scFv) antibody (HW1) that recognizes a different epitope on DR5 form that of TRAIL and induced autophagic cell death. when treated to various cancer cell lines. To study the interaction between TRAIL-induced apoptosis …
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Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations
… in this thesis is two-fold: (i) development of single agents that provide inhibition of both the growth of malaria parasites and of tumour cells in vitro, and (ii) inclusion of these potential novel inhibitors in cyclodextrin host molecules in an attempt to render these dual drugs water-soluble. …
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Distributed coordination of autonomous agents by communicating on a need-to-know basis
Intelligent autonomous agents working cooperatively accomplish tasks more efficiently than single agents, as well as tasks that were infeasible for the single agent. For example, a single agent transporting a ton of blocks will need to take multiple trips, possibly even more trips than it can make, …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… two transgenic mouse models of PCa compared to single agents. Analyses of protein isolated from the ventral prostate of these mice indicated that the combination reduced activation of oncogenic signaling pathways, including STAT3, AKT, and mTORC1 compared to controls. The combination also …
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The significance of the EGFR pathway in malignant pleural mesothelioma
… (MTOR kinase inhibitor) and Celecoxib as single agents and in combinations and analysed using the MTS assay.ResultsPositive 5-LOX expression was seen in 73% and positive 12-LOX expression was seen in 83% of MPM samples. PTEN protein expression was absent in 27% of the samples. A549 cells …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… dual PI3K/mTOR small molecule inhibitors as single agents attenuates UPS cell proliferation, migration, and invasion <em>in vitro</em>. In addition, daily or twice daily drug administration reduces tumor volume and weight in a mouse model harboring a UPS tumor implant. However, single agent …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… present on the cell surface. Currently, approved agents can target and disable ERBB2 receptor function, but as few as 30% of patients with disseminated ERBB2-positive breast cancer will respond to these targeted therapeutics when given as single agents. Even then, many initial responders will soon …
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Investigating the role of the Renin Angiotensin System in cancer
… for metabolic diseases as possible anti-cancer agents. The renin-angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis through Angiotensin Converting Enzyme-1 (ACE-1) and its homolog ACE-2. RAS has also been implicated in the progression of various cancers due to the …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
… Using hu-mice, I show that when administered as single agents, recently discovered broadly neutralizing monoclonal antibodies (bNAbs) induce selective pressure at restricted viral epitopes. This causes a transient drop in viremia and the rapid emergence of viral escape mutants. When bNAbs are …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… are more effective in combination than as single agents. This project examines the effects of combining a novel investigational inhibitor of both complexes MLN0128 that targets mTORC1 and mTORC2, and Trichostatin-A (TSA), a potent inhibitor of both class I and class II HDACs, on the …
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A Green Light at the Intersection of Metal-Organic Frameworks and Drug Delivery
… drug cargoes. Conditions for the loading of single agents as well as chemotherapy cocktails were explored to expand the application of our delivery platform to other cancer types including lung, pancreatic, bladder and cervical. To modulate the release of cargo, a series of MOFs containing …
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CNS Penetration of Tyrosine Kinase Inhibitors in Mouse Models
… effective concentrations of anti-cancer agents to the target site in the brain. The sanctuary of the brain is protected by several barrier systems such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These barriers restrict the passage of anti-cancer …
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