Función del gen Snai3 (Smuc) en la transición epitelio mesenquimal y en cáncer

[EN] The gene Snai3 is a member of the family Snail of factors of trascripción, whose members codify for factors of transcription with fingers of zinc. All of them share a similar organization, being formed by a carboxi-terminal highly preserved region, which contains from four to six of domains in fingers of zinc, and a much more divergent amino-terminal region. The function of the fingers of zinc is it of joining DNA's specific sequences named sequences And Stall, and across this union the proteins of the family Snail are going to be involved in very varied and relevant processes of the development, since it is the transition epithelium mesenquimal. Regarding the gene Snai3, it was described initially in the mouse, and recently it has been described in the human beings and in other species in vertebrates. He was considered to be a member of this family of factors of trascripción due to his homología by the members Snai1 and Snai2. Of the members Snai1 and Snai2 of the family Snail there exist numerous publications that indicate his function in processes as important as are the transition epithelium mesenquimal (EMT), importantly during the embryonic development as during the tumour development, the survival and the genesis of the cancer, the new emergent function of the above mentioned members. Nevertheless, there is not known the paper that Snai3 recovers in the cellular processes.

Author

• Gutsche, Katja

• Tesis y disertaciones académicas
• Molecular biology
• Universidad de Salamanca (España)
• Academic dissertations
• Tumores
• Tumors
• Antioncogenes
• Antioncogens
• ADN
• DNA
• Epitelio
• Epithelium

Identifier

hdl:10366/76287

OAI identifier oai:identifier

oai:gredos.usal.es:10366/76287