Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 791 for “"Epithelium"”.
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Inflammasomes in the Intestinal Epithelium
… the activity of caspases in the intestinal epithelium. Together these data expand upon the knowledge of innate immune signalling in the human intestinal epithelium, enhancing our understanding of how inflammasomes contribute to defense against pathogens and regulation of the intestinal …
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Dynamic Responses at the Barrier Epithelium
… as in mammals, the adult intestinal epithelium is maintained by self-renewing and multipotent stem cells. A critical aspect of the success of adult stem cell renewing systems is the balance and regulation of proliferation, self-renewal, and differentiation. In Chapter 2 we demonstrate …
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In vitro model of periodontal epithelium
To develop a model for junctional epithelium, porcine periodontal ligament epithelial cells (PLE cells) were cultured from the epithelial rests of Malassez. The obtained epithelial cell lines were grown on a porous membrane that allows a good cell adhesion and access of the nutrients from both …
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FUNCTIONAL ADAPTATION OF THE RUMINAL EPITHELIUM
… supports that SCFA are absorbed across the rumen epithelium via passive diffusion or protein-mediated transport, however, the rate and degree to which these pathways adapt to a change in diet fermentability is unknown. Furthermore, Na+ flux is partially determined by SCFA absorption, and thus is a …
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The gallbladder epithelium in experimental cholelithiasis
1. The behaviour of the gallbladder epithelium in three models of experimental cholelithiasis has been studied. The models are : (a) rabbits when fed a lithogenic diet containing 0.75% dihydrocholesterol for 7 days (b) mice when fed a lithogenic diet containing 1% cholesterol and 0.5% cholic acid …
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Genotoxic remodeling of the host epithelium
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Oral epithelium in the pathogenesis of periodontitis
Pocket/sulcular epithelium is the first line of defence to plaque bacteria and its potential role in periodontitis is investigated. This thesis describes the development of a model system, utilising an immortal epithelial cell line (H400) in order to investigate responses to periodontal pathogen …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… that Brk expression in non-transformed mammary epithelium would promote tumorigenesis. To determine the effects Brk expression in the normal mammary gland, we sought to create a mouse model for tissue-specific Brk expression. We expressed a WAP-driven Brk/PTK6 transgene in FVB/n mice, and …
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Vitamin A and glycoproteins of rat corneal epithelium
… pattern was obtained from the rat corneal epithelium; namely, the glycopeptide affected by vitamin A was eluted with 0.4 N LiCl solution by a stepwise column chromatography on DEAE-Sephadex A-50. A specific "peak S" glycopeptide eluted between 0.35 N and 0.42 N LiCl solution was found to be …
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Localization of Cytoskeletal Elements in Teleost Retinal Pigment Epithelium
The G.3.5 antigen (Mr = 100,000) has been localized in brain, cerebellum, skeletal, cardiac, and smooth muscle tissues using the G.3.5 mAb, and has been described as an IFAP on the basis of its co-localization and co-isolation with desmin. Through biochemical analysis, the G.3.5 antigen was found …
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Migration of human tympanic epithelium in health and disease
… migration of keratinised stratified squamous epithelium across the external surface of the human ear drum is an essential function in the maintenance of this delicate membrane by removing dead squamous epithelium to the external meatus for dispersal. The abnormal presence of the same …
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The role of CD133 in mouse incisor tooth epithelium
… of CD133 in the developing mouse incisor epithelium, this project compared the dental epithelial stem cell dynamics of wildtype mice versus CD133 KO mice. Mutant mice displayed significant anomalies across the whole dental epithelium, ultimately, leading to defects in the enamel, the …
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Epigenetic Changes in the Innate Response of Gingival Epithelium
In this study we showed TLR2 CpG promoter methylation in periodontitis affected human gingival tissues and in primary human gingival epithelial cells chronically stimulated with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and …
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Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
… KDM6A generate very large areas of mutant epithelium in aged humans. Further, targeted sequencing revealed dramatic expansion of KRAS-mutant clones in histologically normal colon. Patches may arise from crypt fission and fusion events. Using a clonal mark based on mild periodic acid-Schiff …
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A Proteomic Analysis of Differentiation in the Mammary Epithelium
… governing differentiation of the mammary epithelium into a milk-secreting phenotype. It is important to acknowledge the diversity among the mammary glands of different species in order to better understand applications in human health and the dairy industry. In this study, we examined …
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Investigating factors governing cell fate decisions in respiratory epithelium
The maintenance of the airway/respiratory epithelium during adult homeostasis and repair and its construction during embryonic development require tightly regulated cell fate decisions. This regulation takes the form of complex transcription factor and signalling cascades, much of which are …
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Investigation of respiratory surfactant A protein in middle ear epithelium
… for sound transmission. It is lined by an epithelium which is variable but which resembles that of the lungs. Lung function depends upon surfactant which is a family of surfactant proteins which have an important role in breathing as well as infection control. Given that both the middle ear …
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