Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study

The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2006

Author dc:creator

• Sarkar, Indrani

Contributors dc:contributor

• Buchholz, Frank
• Stewart, Francis
• Hauber, Joachim

• Cre recombinase
• HIV
• directed evolution
• antiretroviral strategy
• Cre Rekombinase
• DNA Evolution
• antiretrovirale Therapie