{"id":{"repo_id":"qucosa-diss","oai_identifier":"oai:qucosa:de:qucosa:24909"},"canonical_url":"https://search.dev.ndltd.org/etd/qucosa-diss/oai:qucosa:de:qucosa:24909","repository":{"repo_id":"qucosa-diss","name":"QUCOSA","base_url":"http://www.qucosa.de/oai/"},"display":{"title":"Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study","abstract":"The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.","abstract_html":"The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy.","abstract_has_math":false,"creators":["Sarkar, Indrani"],"institution":"Technische Universität Dresden","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Buchholz, Frank","Stewart, Francis","Hauber, Joachim"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-09-26","date_published":"2006-09-26","updated_at":"2026-07-24T03:58:35Z","subjects":["Cre recombinase","HIV","directed evolution","antiretroviral strategy","Cre Rekombinase","DNA Evolution","antiretrovirale Therapie"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Buchholz, Frank","Stewart, Francis","Hauber, Joachim"]},{"key":"dc:creator","label":"Author","values":["Sarkar, Indrani"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden","Technische Universität Dresden"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Technische Universität Dresden"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cre recombinase","HIV","directed evolution","antiretroviral strategy","Cre Rekombinase","DNA Evolution","antiretrovirale Therapie"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy."]},{"key":"dc:title","label":"Title","values":["Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study"]}]}],"canonical_facts":{"dc:contributor":["Buchholz, Frank","Stewart, Francis","Hauber, Joachim"],"dc:creator":["Sarkar, Indrani"],"dc:description.abstract":["The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination proficiency of the evolved recombinase in mammalian cells and explore the potential of the recombinase for a novel antiretroviral strategy."],"dc:publisher":["Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden","Technische Universität Dresden"],"dc:subject":["Cre recombinase","HIV","directed evolution","antiretroviral strategy","Cre Rekombinase","DNA Evolution","antiretrovirale Therapie"],"dc:title":["Directed evolution of an HIV-1 LTR specific recombinase for anti-retroviral therapy- a proof of concept study"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Technische Universität Dresden"]},"updated_at":"2026-07-24T03:58:35Z"}