Autophagic degradation of peroxisomes in the alkane-assimilating yeast Yarrowia lipolytica

The thesis is aimed at understanding of molecular mechanisms of autophagic degradation of peroxisomes (pexophagy) in the yeast Yarrowia lipolytica. This microorganism has been extensively used to explore peroxisome biogenesis (Titorenko and Rachubinski, 2000). Gunkel et al. (1999) intoduced Y. lypolitica into pexophagy studies. However, the field of pexophagic research on this yeast remains quite unexplored. This work involved following tasks: (1) the development and optimization of Y. lipolytica as a model system to study peroxisome degradation; (2) Y. lipolytica genes and proteins implicated in pexophagy should be found and characterized; (3) a proper easy-to-handle selection procedure to isolate novel peroxisome degradation-deficient(pdd) mutants of Y. lipolytica should be devised.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Technische Universität Dresden

Year

2006

Author dc:creator

• Parshyna, Iryna

Contributors dc:contributor

• Barth, Gerold
• Veenhuis, Marten
• Rachubinski, Richard

• Peroxisome
• pexophagy
• autophagy
• Yarrowia lipolytica
• pdd mutant
• Peroxisom
• Pexophagie
• Autophagie