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Showing 1 to 6 of 6 for “"pexophagy"”.
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The Mechanism of Mammalian Pexophagy
The mechanism of mammalian pexophagy is poorly understood. Although ubiquitination is thought to be involved in the process, the upstream and downstream effectors of ubiquitination remain elusive. Specifically, the E3 ligase responsible for mediating ubiquitination is not known, the site(s) of …
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Investigation of pexophagy and autophagy occurrence in Arabidopsis
… of peroxisomes through this process is called pexophagy. By comparing protein accumulation in various peroxin mutants to accumulation in both wild type and seedlings incapable of autophagy (atg mutants), I found that pex2, pex4, pex10, and pex14 mutants stabilized several peroxisomal proteins …
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Autophagic degradation of peroxisomes in the alkane-assimilating yeast Yarrowia lipolytica
… of autophagic degradation of peroxisomes (pexophagy) in the yeast Yarrowia lipolytica. This microorganism has been extensively used to explore peroxisome biogenesis (Titorenko and Rachubinski, 2000). Gunkel et al. (1999) intoduced Y. lypolitica into pexophagy studies. However, the field of …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… membrane, where it counteracts mitophagy and pexophagy by cleaving ubiquitin chains from target proteins. Here I characterise T cell motility, signalling, energy requirements and cytotoxicity in CD8+ T cells derived from splenocytes of Usp30-/- mice. Furthermore, I test different mitochondrial …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… and Usp30, involved in mitophagy and pexophagy. A further 4 genes were identified as increasing the lytic capacity of CTL and included: Arpc1b, involved in actin filament branching; Bach2, a transcriptional regulator; Lrrc8d, a component of the volume-regulated anion channel and Oaf, …
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Aging Lowers Pex5 Levels In Cortical Neurons In Male and Female Mouse Brains
<p>Peroxisomes are small organelles with critical functions: lipid synthesis, breakdown of reactive oxygen species by antioxidant enzymes, and amino acid degradation. In the brain, peroxisomal lipids make up the myelin sheath. Brain peroxisomal dysfunction leads to lipid disruption or neurological …