Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 491 for “"autophagy"”.
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The study of two transmembrane autophagy proteins and the autophagy receptor, p62
Autophagy is an evolutionarily conserved process across eukaryotes that is responsible for degradation of cargo such as aggregate-prone proteins, pathogens, damaged organelles, macromolecules etc. via its delivery to lysosomes. The process is known to involve the formation of a double-membraned …
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Autophagy in Antiviral Immunity
Autophagy is an evolutionarily conserved pathway in which cytoplasmic material is sequestered in a double-membrane vesicle and delivered to the lysosome for degradation. During times of stress, autophagy functions to generate essential nutrients through the degradation of non-essential cytoplasmic …
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Autophagy gridlock in tauopathy
… of aggregation-prone proteins can occur via autophagy. Here, we utilized the previously developed model of human tauopathy in Drosophila to examine how autophagy modulates human tau toxicity and to study the effects of human tau on the autophagic machinery. We showed that caloric restriction …
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Mechanisms of Adenovirus-Mediated Autophagy
… of cell death urgently need to be explored. Autophagy, which is also known as programmed cell death type II, has recently been identified as an alternative mechanism to kill apoptosis- resistant cancer cells. Traditionally, researchers have studied how cells undergo autophagy during viral …
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Mechanisms of Adenovirus-Mediated Autophagy
… of cell death urgently need to be explored. Autophagy, which is also known as programmed cell death type II, has recently been identified as an alternative mechanism to kill apoptosis- resistant cancer cells. Traditionally, researchers have studied how cells undergo autophagy during viral …
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Mathematical modelling of autophagy pathway.
A system modelling autophagy is a new area of research. Current understanding of each step in this biochemical pathway is limited. The study of this mechanism is interesting in several aspects: autophagy plays an important role in physiological cellular processes, is a survival mechanism under …
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Autophagy and Inflammation During Rickettsial Infection
… my dissertation, I have studied the induction of autophagy by rickettsiae as well as the role of autophagy in the pathogenesis of rickettsioses in vitro and in vivo. I found that autophagy is induced in murine bone marrow macrophages (BMMs) upon infection with R. australis and bacteria are …
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Regulators of autophagy in Leishmania major
Autophagy is a conserved lysosomal degradation pathway for recycling long-lived proteins and organelles that is thought to be required for life cycle progression and virulence of Leishmania. ATG8 is a ubiquitin like protein that is required for the formation of autophagosomes, and Leishmania …
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Autophagy in the developing Drosophila brain
Autophagy is the process by which a cell sends cytosolic material to the lysosome for digestion. In this work, I investigated the importance of autophagy to lipid droplet formation and protein turnover in the neural stem cells, neurons, and glia of the larval Drosophila brain. The role of the …
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The Role of Calcium Signalling in Autophagy
Autophagy is a catabolic process that is important for degradation of cellular components, and for cell survival, and has also been associated with pathological disorders and tumour growth. Autophagy is a complex process; many factors and messengers converge to control steps along the autophagic …
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The role of autophagy in canine osteosarcoma
… abnormalities. We have previously shown that autophagy plays a major role in promoting the development of osteosarcoma in humans, however, its role canine in osteosarcoma is unclear. Targeting autophagy as an anticancer therapy is complicated by its nature of dual role: activating autophagy …
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Molecular analysis of vesicle biogenesis during autophagy
Autophagy in Saccharomyces cerevisiae comprises diverse processes that transport cytoplasm and even organelles into the vacuolar lumen for degradation. During macroautophagy out of the pre- autophagosomal structure (PAS) autophagosomes are formed that fuse with the vacuole for degradation. During …
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Atg11 and Atg9 interaction in selective autophagy
<p>Selective autophagy, induced by cellular stresses, degrades/recycles a specific cargo. Ithelps prevent diseases like Parkinson’s, Huntington's, cancer, and bacterial infections. It involves the formation of an autophagosome, a double-membrane vesicle that takes the cargo to the vacuole/lysosome …
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Autophagy in Metabolism, Cell Death, and Leukemogenesis
… and cells activate the self-digestive process of autophagy, which clears damaged organelles and provides degradation products as an alternate fuel to support mitochondrial metabolism. Importantly, loss of growth signals can also lead to apoptosis mediated through Bcl-2 family proteins, and Bcl-2 …
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Autophagy and Lipid Homeostasis in C. elegans
… the conserved cellular recycling process of autophagy has been linked to several lipid-related metabolic disorders, including insulin resistance, fatty liver disease, atherosclerosis, and obesity. Autophagy plays a complex role in lipid metabolism as it contributes to both lipid storage and …
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Copper ionophores induce autophagy in melanoma cells.
… other avenues of cell death were pursued, namely autophagy, a mechanism in which a cell devours itself in times of stress. In this study, two copper ionophores, disulfiram and thiomaltol, were investigated against melanoma. By using immunocytochemistry, Western Blotting and supravital staining, it …
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A study on non-canonical autophagy signalling
… of all resources upon nutrient depletion. Autophagy is an essential catabolic process induced to provide cellular energy sources in response to nutrient limitation through the engulfment of intracellular content in double-membrane vesicles known as autophagosomes, which fuse with lysosomes …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… of the pathway also induces noncanonical autophagy. Despite an increasing body of research on STING-induced noncanonical autophagy, our understanding of its mechanisms, and particularly its functions, remains limited. In this study, we demonstrated that STING-induced noncanonical autophagy …
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Autophagy in Zellweger Syndrome Spectrum Disorder and Cancer
Autophagy is a lysosomal degradation pathway that breaks down unwanted proteins and organelles from the cytoplasm to regenerate cellular building blocks. This process is constitutively active at low basal levels, and can be upregulated by stress stimuli to promote cellular homeostasis. In this …
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Investigation of pexophagy and autophagy occurrence in Arabidopsis
… how this organelle is regulated remains limited. Autophagy is a cellular system that targets components of the cell for degradation in the vacuole (of plants or yeast) or the lysosome (of animals). Autophagy can be selective, and the degradation of peroxisomes through this process is called …
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