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Showing 1 to 20 of 31 for “"Peroxisomes"”.
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Autophagic degradation of peroxisomes in the alkane-assimilating yeast Yarrowia lipolytica
… mechanisms of autophagic degradation of peroxisomes (pexophagy) in the yeast Yarrowia lipolytica. This microorganism has been extensively used to explore peroxisome biogenesis (Titorenko and Rachubinski, 2000). Gunkel et al. (1999) intoduced Y. lypolitica into pexophagy studies. However, …
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Proteome studies on leaf peroxisomes from Spinacia oleracea L. and Arabidopsis thaliana (L.) Heynh.
Im Rahmen der vorliegenden Arbeit wurde eine Proteomanalyse von pflanzlichen Peroxisomen begonnen, um unser Verständnis der Funktionen dieser ubiquitären eukaryotischen Zellorganellen zu erweitern. Ein überlieferte Methode zur Isolierung von Blattperoxisomen aus Spinacia oleracea L. wurde durch …
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Subcellular and functional analyses of two small heat shock proteins and protein kinases from peroxisomes of Arabidopsis thaliana L.
Um neue Erkenntnisse über die Rolle von molekularen Chaperonen und eine mögliche post-translationale Regulation des Peroxisomen-Stoffwechsels zu gewinnen, wurde mit Hilfe einer in silico Analyse das Arabidopsis Proteom nach regulatorischen Proteinen durchsucht, welche eine mögliche …
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Morphological and histochemical observations of hepatic peroxisomes and lysosomes of rats after treatment with methylmercuric chloride, hydrogen peroxide and gamma radiation
… of cytochemically identified hepatic peroxisomes and lysosomes was studied at days 2, 7 and 21 following treatment with hydrogen peroxide (HP), methylmercuric chloride (MMC) and gamma radiation (I). The HP group received five daily intraperitoneal (IP) injections of 1.8 ml of 1.5% HP; …
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Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet development
The roles of peroxisomes and microsomes on the biosynthetic pathway for docosahexaenoic acid (DHA) from [Alpha]-linolenic acid (ALA) were investigated. Microsomes and peroxisomes were prepared from livers of fetal and neonatal piglets by a combination of differential and gradient layer …
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The circadian role of Pex5 in glial cells and implications of Pex5 in sleep behavior and brain lipidome
Peroxisomes are critical organelles that detoxify cellular waste while also catabolizing and anabolizing lipids. How peroxisomes coordinate protein import and support metabolic functions across complex tissues and timescales remains poorly understood in vivo. Using the Drosophila brain, we discover …
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Investigation of pexophagy and autophagy occurrence in Arabidopsis
Peroxisomes are critical organelles, housing various essential processes conserved across multicellular organisms. Most notable reactions include fatty-acid -oxidation and the detoxification of reactive oxygen species generated as byproducts from diverse oxidative reactions. Peroxisomes also house …
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Aging Lowers Pex5 Levels In Cortical Neurons In Male and Female Mouse Brains
<p>Peroxisomes are small organelles with critical functions: lipid synthesis, breakdown of reactive oxygen species by antioxidant enzymes, and amino acid degradation. In the brain, peroxisomal lipids make up the myelin sheath. Brain peroxisomal dysfunction leads to lipid disruption or neurological …
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Investigation Of The Interconnected Roles Of Cmal And Hopaa1-1 In The Virulence Of Pseudomonas Syringae Pv.Tomato Dc3000 In Nicotiana Benthamiana
… HopAA1-1 was found to colocalize with plant peroxisomes. Truncated derivatives of HopAA1-1 that are not cytotoxic and cannot promote symptom formation do not localize with peroxisomes. Additionally, other truncated derivatives of HopAA1-1 colocalize with the endoplasmic reticulum in addition …
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The Biogenesis of Peroxisomal Catalase in Rat Liver
… homogeneity. The starting material was purified peroxisomes, The purity of the final preparation was judged by Sephadex G-200 chromatography, SDS gel electrophoresis, spectral analysis, and immunochemical means. Two sera containing anticatalase antibodies were prepared. The first, a rabbit serum, …
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The Conserved Oligomeric Golgi (COG) Complex Is Required for Normal Import of Fatty Acids in Saccharomyces Cerevisiae
… mechanism of trafficking of membrane proteins to peroxisomes. The work described in this document centers around one protein from Saccharomyces cerevisiae, Cog7p. Cog7p is part of the conserved oligomeric Golgi (COG) complex. Results describing a basic function of Cog7p were published well after I …
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Biochemical characterization of the first step in ether lipid biosynthesis: acylation of dihydroxyacetone phosphate
… dihydroxyacetone phosphate, resides in peroxisomes. The principal function of DHAPAT in mammals is the biosynthesis of ether-based lipids which are widely distributed in the body and noticeably abundant in membranes of the nervous system. Compared to the four GPATs, DHAPAT is …
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Screening and Engineering Phenotypes using Big Data Systems Biology
… the local availability of acetyl-CoA in the peroxisomes of yeast was quantified by the production of polyhydroxybutyrate (PHB) using three heterologous enzymes. The resulting assay demonstrated the differences in acetyl-CoA availability in the peroxisomes under various culture conditions and …
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A Mutant of Arabidopsis Thaliana Deficient in Chloroplast Dicarboxylate Transport Activity
… occurring in three organelles, chloroplasts, peroxisomes, and mitochondria. This pathway therefore provides a unique opportunity for studying transport systems and their role in mediating interactions between organelles. This study is concerned with the characterization and physiological …
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Investigating Differentiation: A Role for Organelle Inheritance in Epidermal Growth
… deeper, we discovered that without PEX11b, peroxisomes function, but fail to segregate properly. Intriguingly, peroxisome localization is directly coupled to mitotic progression, and when peroxisomes are ectopically mis-localized, mitotic abnormalities occur. Together, our findings unveil a …
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Functional characterisation of NIC2, a member of the MATE family from Arabidopsis thaliana (L.) Heynh.
… level NIC2-GFP fusion protein localised in the peroxisomes of Nicotana tabacum BY2 protoplasts. Considering the experimental results, it is proposed that the hypothetical function of NIC2 is the efflux transport which takes part in the auxin homeostasis in plant tissues probably by removing …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… inhibited IRF1 nuclear translocation. Peroxisomes are the innate antiviral signaling platforms for activation of IRF1-mediated IFN-λ production, and they were found to decrease in number in PEDV-infected cells. PEDV nsp1 blocked the nuclear translocation of IRF1 and reduces the number …
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THE ROLE OF ALPHA OXIDATION IN LIPID METABOLISM
… carbon unit from a fatty acid chain within the peroxisomes. To better understand the correlations and interactions between these two fatty acids with pathological development, the origin of these odd chain fatty acids needed to be determined, along with confirming their association with the …
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Role of Acetyl-L-Carnitine in Hepatic Encephalopathy
… is endogenously produced within mitochondria and peroxisomes and is involved in the transport of acetyl-moieties across the membranes of these organelles. Acetyl-L-carnitine administration has shown the recovery of neuropsychological activities related to attention/concentration, visual scanning …
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Studying Processive Molecular Motors Inside Live Cells
… bound to the motors. Fluorescently labeled peroxisomes and dark pigment carrying melanosomes can be tracked in vivo with high spatial (∼1.5 nm) and temporal (∼1 msec) resolution by the derivatives of FIONA. This has enabled us to resolve the stepwise motion of motor proteins …
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