Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates

p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle.

Name thesis:degree_name

Doctor of Science (DSc)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Physical Therapy

Year

2013

Author dc:creator

• Cavalcanti, Paula Regina Aguiar

Contributors dc:contributor

• Berk, Lee S.
• Daher, Noha S.
• Lohman, Everett
• Petrofsky, Jerrold S.

• Physical Therapy
• Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;
• Sleep-wake cycle
• Salivary melatonin
• circadian rhythms
• Homeostatic rhythms
• Rhythm fragmentation

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/116

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-1115