Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"melatonin"”.
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Melatonin and seasonal cycles in muskoxen
… characterize the annual reproductive cycle and melatonin rhythm in muskoxen at 52°N and to investigate the role of photoperiod in timing seasonality. During the first part of the study, changes in reproductive function and circulating melatonin patterns were studied in 15 tame muskoxen. …
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The role of melatonin in peripartum cardiomyopathy
… stress contributes to the pathogenesis of PPCM. Melatonin is a powerful endogenous antioxidant that can limit the damaging effect of oxidative stress. Melatonin levels are known to be altered in sleep disruption, depression and other cardiac diseases. The aim of this study was to determine if …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
… PH and novel therapies are urgently needed. Melatonin is a powerful antioxidant that can confer benefit against ischemia-reperfusion injury and hypertension. We therefore hypothesised that melatonin may confer cardiovascular benefits against PH. Methods: Oxidative stress (plasma lipid …
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The role of melatonin in red wine-induced cardioprotection
… The aim of the study was to explore whether melatonin, recently discovered in red wine, may play a vital role in red wine-induced cardioprotection. Furthermore, we propose that the protective effect may be mediated via the activation of the survivor-acting factor enhancement (SAFE) pathway …
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Effect of Melatonin on Differentiation of Human Mesenchymal Stem Cells and a Study on C-Terminal Domains of MT1 and MT2 Melatonin Receptors
Melatonin has been reported to enhance the differentiation of osteoblasts. The purpose of this study was to determine the melatonin treatment that would differentiate human mesenchymal stem cells (hAMSCs) into osteoblasts. A 21 d continuous melatonin treatment significantly increased the alkaline …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… the protective effects of pifithrin-α and melatonin against doxorubicin-induced cardiotoxicity. Doxorubicin was injected at a dose of 22.5 mg/kg (i.p.) in mice to induce cardiotoxic effects. Meanwhile, doxorubicin caused a significant increase of cardiac cell apoptosis following injection …
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Sleep disorders and melatonin secretion-excretion patterns in children with epilepsy /
… to epilepsy. In the clinical practice, synthetic melatonin is prescribed for treatment of sleep disorders in children with epilepsy. Clinical trials suggest that melatonin may shorten the duration to sleep onset and balance the sleep structure, leading to decrease in the number of epileptic …
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Cellular Mechanisms Underlying the Action of Melatonin in the Suprachiasmatic Nucleus
The pineal hormone melatonin was extracted in 1958 from the bovine pineal gland. Ever since it has received vast popular attention as a hormone with beneficial effects on sleep disorders, jet lag and longevity. Recent attention has focused on its role in circadian physiology. The suprachiasmatic …
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Daily Nocturnal Melatonin Supplementation in Perimenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Study Examining the Effects of Melatonin on Bone Health and Quality of Life
… pilot study was to assess the effects of nightly melatonin supplementation on primary endpoints of bone health and secondary endpoints of quality of life in perimenopausal women. </p><p> Methods: A total of 18 perimenopausal women were randomized to receive melatonin, 3 mg p.o., (n=13) or placebo …
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Menopausal Transition: Psychosocial Aspects and the Role of Melatonin in Psychogenic Symptoms
… part in Study 2. Their evening on-set salivary melatonin secretion levels were compared, as was their exposure to natural light at 500, 3,000 and 10,000 lux levels, their subjective and objective (wrist actigraph) sleep quality and their nocturnal peripheral body temperatures (PBT). Results from …
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Aptamer-Based Detection of Salivary Melatonin for Circadian Rhythm Sleep Disorders Monitoring
… to the disruption of daily levels of circulating melatonin. Current circadian rhythm sleep disorder diagnostic approaches are typically based on questionnaires (which lack objectivity), and/or on dim light melatonin onset tests (which are costly, cumbersome, and lack sensitivity), thereby leaving …
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Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates
… were significant inverse relationships between melatonin collected at two hours before bed time and latency (Ï=-.87; p=.001), wake after sleep onset (Ï =-.69; p=.02) and nocturnal activity (Ï =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (Ï =-.69; …
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Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury
Introduction: The presence of melatonin in wine contributes to the cardioprotective effect of regular and moderate consumption of wine against lethal ischemia/reperfusion injury. Recently, the presence of melatonin isomers has been identified in red wine, but whether or not these isomers confer any …
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Amphiphilic Diblock Copolymers: Study of Interpolyelectrolyte Complexation in Organic Media and Nanoencapsulation of Melatonin
… complexation. Finally, nanocapsules loaded with melatonin were fabricated using a simple nanoprecipitation route employing a mixture of a diblock copolymer based on poly(methyl methacrylate) and PDMAEMA (PMMA-b-PDMAEMA) in combination with poly(ε-caprolactone), PCL. The diblock copolymers were …
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Gene expression underlying ferret hair growth initiation induced by melatonin and modified by steroids
… ferret winter pelage development induced by melatonin was utilised as an in vivo model for studying gene expression associated with the hair growth cycle. The effects of melatonin and steroids on hair follicle growth initiation in flank skin samples were monitored by histology and …
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The effects of melatonin injection on glucose tolerance in intact and pinealectomized laboratory rats
Studies on rat islet preparations have shown melatonin inhibits MAO activity and thereby reduces glucose mediated insulin release. The objective of this work is to investigate the effects of melatonin on insulin release, and on glucose mediated insulin release in the intact and in the …
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Effect of Melatonin and Dopamine in Site Specific Phosphorylation of Phosducin in Intact Retina
… to the process of light adaptation. Dopamine and melatonin are neuromodulators whose concentrations in the retina vary reciprocally during the circadian cycle, with dopamine high during the day and melatonin high during the night. Together, they control numerous aspects of light and dark …
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