{"id":{"repo_id":"loma-linda","oai_identifier":"oai:scholarsrepository.llu.edu:etd-1115"},"canonical_url":"https://search.dev.ndltd.org/etd/loma-linda/oai:scholarsrepository.llu.edu:etd-1115","repository":{"repo_id":"loma-linda","name":"Loma Linda University","base_url":"https://scholarsrepository.llu.edu/do/oai/"},"display":{"title":"Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates","abstract":"p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle.","abstract_html":"p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle.","abstract_has_math":false,"creators":["Cavalcanti, Paula Regina Aguiar"],"institution":null,"degree_name":"Doctor of Science (DSc)","degree_level":"Dissertation","degree_discipline":"Physical Therapy","degree_department":null,"school":null,"contributors":["Berk, Lee S.","Daher, Noha S.","Lohman, Everett","Petrofsky, Jerrold S."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-06-01T07:00:00Z","date_published":"2013-06-01T07:00:00Z","updated_at":"2026-07-24T02:52:15Z","subjects":["Physical Therapy","Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;","Sleep-wake cycle","Salivary melatonin","circadian rhythms","Homeostatic rhythms","Rhythm fragmentation"],"languages":["English"],"rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsrepository.llu.edu/etd/116","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Berk, Lee S.","Daher, Noha S.","Lohman, Everett","Petrofsky, Jerrold S."]},{"key":"dc:creator","label":"Author","values":["Cavalcanti, Paula Regina Aguiar"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Physical Therapy"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Science (DSc)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Physical Therapy","Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;","Sleep-wake cycle","Salivary melatonin","circadian rhythms","Homeostatic rhythms","Rhythm fragmentation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsrepository.llu.edu/etd/116"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle."]},{"key":"dc:title","label":"Title","values":["Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates"]}]}],"canonical_facts":{"dc:contributor":["Berk, Lee S.","Daher, Noha S.","Lohman, Everett","Petrofsky, Jerrold S."],"dc:creator":["Cavalcanti, Paula Regina Aguiar"],"dc:description.abstract":["p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian alterations of the sleep-wake cycle."],"dc:identifier":["https://scholarsrepository.llu.edu/etd/116"],"dc:language":["English"],"dc:rights":["This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights."],"dc:subject":["Physical Therapy","Diabetes Mellitus, Type 2; Circadian Rhythm; Sleep physiology; Melantonin - physiology;","Sleep-wake cycle","Salivary melatonin","circadian rhythms","Homeostatic rhythms","Rhythm fragmentation"],"dc:title":["Sleep-wake Cycle Assessment in Type 2 Diabetes and Salivary Melatonin Correlates"],"thesis:degree_discipline":["Physical Therapy"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Science (DSc)"]},"updated_at":"2026-07-24T02:52:15Z"}