Δυναμική ταξινόμηση των μορφών της νόσου του Paget των οστών και η θεραπευτική αντιμετώπισή τους

We propose a new dynamic radiological classification of Paget's disease. This classification incorporates the traditional radiological phases of bone turnover or remodelling: that is, the osteolytic phase, the mixed phase, and the osteoblastic phase. Normal or diminished bone scan activity in the osteoblastic phase indicates diminished bone turnover which we distinguish as the osteosclerotic phase. Modelling states or bone deformities of expansion or contraction are recorded as a function of bone drift at the periosteal and endosteal envelopes. A case of Pagetic bone contraction is documented. Out of a series of 112 symptomatic patients, 527 Pagetic bones were classified. Eighty-eight patients were treated medically; twenty showed progression to a more bone forming phase without a change of the modelling state, and twelve patients showed regression to an increasing bone resorptive phase. No treated patient returned to normal bone architecture. Unusual radiological manifestations of Paget's disease are incorporated into the dynamic classification. Of the drugs for the treatment of the disease available diphosphonates (EHDP) seem to be the more appropriate for the convenience of use, the absence of refractory effects and the alimination of complications, although calcitonin and mithramycin, within their limitations, have their indications in dealing with this peculiar but crippling disease.

Grantor dc:publisher

University of Patras

Year dc:date

1990

Authors dc:creator

• Sagiakos, Ioannis
• Σαγιάκος, Ιωάννης

• Ακτινολογικές φάσεις
• Μονάδα οστικής αναδόμησης
• Νόσος του Paget
• Οστεοβλάστες
• Οστεοκλάστες
• Οστικά περιβλήματα
• Οστική αναδόμηση
• Οστικός μετασχηματισμός
• Bone envelopes
• Bone modelling
• Bone remodeling
• Bone remodelling unit
• Osteoblast
• Osteoclast
• Paget's disease
• Radiological phases
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1314

OAI identifier oai:identifier

oai:10442/1314