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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"Osteoclast"”.
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The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity
Osteoclasts are multinucleated cells that resorb bone and carry out their function via a dynamic actin cytoskeleton that is regulated by Rho GTPases. Rho GTPases function as molecular switches that regulate the actin cytoskeleton in osteoclasts and many other cell types. A Rac GTPase validation …
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Cytoskeletal organization in the osteoclast
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effect of blueberry polyphenols on osteoclast
Bone is a dynamic tissue with osteoblasts and osteoclasts participating concomitantly in its remodeling process. Blueberries are a rich source of polyphenolic compounds and have been shown to be effective in decreasing incidence/symptoms of chronic inflammatory conditions. The purpose of this study …
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
… via complex coupled actions of bone-resorbing osteoclasts and bone-forming osteoblasts. Loss of coupling between bone formation and bone resorption leads to pathogenesis of bone metabolic diseases including osteoporosis or osteopetrosis. Defects in osteoclast activity, whether increased …
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In vitro osteoclast resorption of calcium phosphate bone substitutes
… aim of this work was to investigate the in vitro osteoclast (OC) resorption of calcium phosphate (CaP) biomaterials. Resorption of CaP biomaterials is traditionally assessed using an OC resorption assay where resorption pits formed on the CaP surface are analysed by microscopy techniques and …
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Sex-specific gene expression and its effect on osteoclast maturation
<p>Osteoclasts lie at the root of abnormal bone loss associated with osteoporosis. Osteoporosis primarily affects women and develops when estrogen, a negative regulator of osteoclast life cycle, plummets with menopause. In addition to the role of estrogen, the existence of inherent differences …
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Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
… would benefit a wide variety of patients. Osteoclasts resorb mineral in vivo and we hypothesized that a cell therapy based on inducible osteoclast differentiation could be used as a cell therapy to treat EC and HO. The RANK/RANKL pathway is a critical step in osteoclast differentiation and …
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Early Osteoclast Responses to a Calcium Supplemented Meal in Calcium Deficient Rats
<p>Osteoclasts are large, irregularly-shaped, multinucleated cells. They are the primary cells responsible for the mobilization of calcium from bone (bone resorption). It is a well known fact that bone diseases (i.e. osteoporosis and osteopetrosis) occur as a result of unbalanced cellular activity. …
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Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
… abundance of these cells in the bone marrow. Osteoclasts are bone-resorbing cells formed from the fusion of macrophages in a process known as osteoclastogenesis. Herein, we hypothesized that multiple myeloma cells promote osteoclastogenesis through direct mechanisms by secreting RANKL, the …
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Expression of Capn6 During Osteoclast Differentiation In Wild-Type and Hdac4 Knockout Mice
Introduction: The process of osteoclast differentiation consists of a network of complex signaling pathways. Previous studies suggest HDAC proteins play a suppressive role in osteoclast differentiation; however, not much is known about the specific role of HDAC4. Capn6 has been linked to increased …
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The role of autophagy in protecting periodontium integrity, and lipopolysaccharide-induced osteoclast differentiation
… stem cells concerned in both osteogenesis and osteoclastogenesis are different, they both originate from the bone marrow, therefore the same primary human bone marrow cells containing the specific stem cell populations required for osteogenesis or osteoclastogenesis were used to establish in …
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Characterization of the Developmentally Regulated Osteoclast Support Potential of In Vitro Medullary Adipocytes
… potential for medullary adipocytes to regulate osteoclast development was tested. Factors important in osteoclast development including RANKL, M-CSF and OPG were expressed by in vitro medullary adipocytes. Furthermore, the expression of these important osteoclast mediators was only observed in a …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
As mammals age, osteoblast numbers decrease while osteoclast numbers increase, resulting in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for …
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Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
Increased osteoclast (OC) bone resorption and/or decreased osteoblast (OB) bone formation contribute to bone loss in osteoporosis and rheumatoid arthritis (RA). Findings of the basic and translational research presented in this thesis demonstrate a number of mechanisms by which cytokine-induced …
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Effects of Dietary Calcium and Fasting on Osteoclast Recession and Recruitment in Calcium Deficient Rats
<p>The osteoclast, a multinucleated giant cell, has as its role the resorption of bone matrix with consequent release of calcium. The osteoclast is thought to derive from a pluripotent stem cell which also gives rise to monocytes and macrophages. The development, activation, and inhibition of …
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The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
Osteoclasts are large multinucleated cells that resorb or degrade bone. Over-active osteoclasts result in fragile bones that fracture easily, causing bone degenerative disorders such as osteoporosis. Inhibiting osteoclast activity represents a viable strategy to combat bone degeneration. When the …
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