Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 180 for “"Osteoblast"”.
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Exploration of the mouse osteoblast transcriptome
Contains fulltext : 30023.pdf (Publisher’s version ) (Open Access)
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The Regulation of Glucose Metabolism during Osteoblast Differentiation
… the alterations of cellular metabolism in osteoblast-lineage cells in response to two different bone anabolic signals, WNT and PTH. I have further elucidated the mechanism underlying the metabolic changes, and have explored the functional importance of such changes for bone anabolism.</p> …
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Regulation of osteoblast activity by Pyk2-targeted approaches
… tyrosine kinase 2 (Pyk2) is important for osteoblast (OB) activity and bone formation. However, female mice lacking Pyk2 (Pyk2-KO) exhibit elevated bone volume/total volume. Previously, our laboratory found ovariectomized Pyk2-KO mice supplemented with 17β-estradiol (E2) exhibited a greater …
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Characterizing slc8a4b as an Osteoblast Marker in Danio rerio
… 8 member 4b (slc8a4b) is an emerging marker for osteoblasts in zebrafish, enabling further study of healthy bone development, bone regeneration, and skeletal diseases. To guide future use of slc8a4b as an osteoblast marker, this study aims to identify which osteoblast functions slc8a4b expression …
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Effects of Neurotrophic Factors on Osteoblast Growth and Differentiation
… These neuropeptides could act locally on osteoblasts to increase bone formation and/or mineralization. Since calcitonin gene-related peptide (CGRP) and Substance P (SP) are the most abundant neuropeptides present in sensory nerves in bone, the current studies were intended to test the …
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Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate
… postulated to be osteogenic factors that enhance osteoblast differentiation and mineralization. Recently, a zirconia-hybridized pyrophosphate stabilized amorphous calcium phosphate (Zr-ACP) has been synthesized which permits controlled release of calcium and phosphate ions and thus is hypothesized …
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Influence of static and dynamic topography on osteoblast proliferation and maturation
… recovery within 8 hours. The examination of pre-osteoblast MG63 cell behavior on these SMPs (with and without compression) by DNA and ELISAs indicates MG63 cells can be 'clued' to proliferate and then to rapidly mature. Similar topography was created on polymers of varied stiffness to determine …
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Development of poly(3-octylthiophene) thin films for regulating osteoblast growth
… (P3OT) to sustain MC3T3-E1 osteoblast attachment and growth. The central hypothesis was that specific P3OT film properties (i.e., thickness, film preparation conditions, and level of doping) are able to regulate osteoblast functions (i.e., attachment and proliferation). …
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The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… signaling, we unexpectedly uncovered a role for osteoblasts in regulating cytokine-induced mobilization. By isolating and sorting different fractions of bone marrow stromal cells we demonstrate that osteoblasts represent a major source of CXCL12 in the bone marrow. In addition, both the number …
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
… (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter activity was mediated by a composite response element that has binding sites for transcription factor activator protein 2 (AP-2) and nuclear …
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The role of alpha-actinnin in osteoblast survival signaling and mechanotransduction
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Rooibos tea flavonoids increase mineral content in human osteoblast-like cells
… that could enhance mineral content in human osteoblast Saos2 cells. Mineral was quantified by alizarin red staining and characterized by quantifying alkaline phosphatase (ALP) activity, cell mitochondria activity and toxicity, in addition to changes in regulatory markers of osteoblastic …
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The effect of bone anabolic stimuli on human osteoblast to osteocyte transition.
… or pro-catabolic response in human primary osteoblasts (Normal Human Bone-derived Cells, NHBC), concomitant with the acquisition of an OY-like phenotype (2-6). Bone mineralisation, the deposition of calcium and phosphate as calcium phosphate in the form of hydroxyapatite, occurs in lamellar …
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Procollagen Biosynthesis and Osteoblast Malfunction in the G610C Mouse Model of Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a hereditary disease that disrupts bone formation and function resulting in skeletal deformities and fragile bones. OI is diagnosed based on clinical and radiological examination, with patient symptoms ranging in severity from relatively mild (increased incidence of …
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