ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS

THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL MORPHOLOGY OF THE REGENERATE, AFFECTING THE PATTERN FORMATION. C) THE EFFECT OF CARCINOGENS ON LIMB REGENERATION IS STRICTLY LOCAL. D) CARCINOGENS MNNG AND 4NQO CAUSE PERMANENT CHANGES ON PATTERN FORMATION. E) THE TISSUES OF REGENERATING LIMBS AND THE TISSUES OF THE INTACT LIMB WHICH HAVE REGENERATING ABILITY SHOW INCREASED RESISTANCE TO THE EFFECTS OF CARCINOGENIC SUBSTANCES.

Grantor dc:publisher

Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

Year dc:date

1990

Author dc:creator

• Ζηλάκος, Νικόλαος

• AMPHIBIA
• Carcinogenesis
• LIMBREGENERATION
• PATTERN FORMATION
• Teratogenesis
• ΑΝΑΓΕΝΝΗΣΗ ΑΚΡΩΝ ΑΜΦΙΒΙΩΝ
• ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ
• ΤΕΡΑΤΟΓΕΝΝΕΣΗ ΑΚΡΩΝ
• Natural Sciences
• Biological Sciences
• Φυσικές Επιστήμες
• Βιολογία

Language dc:language

gre

Identifier

10.12681/eadd/1300

OAI identifier oai:identifier

oai:10442/1300