{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1300"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1300","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS","abstract":"THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL MORPHOLOGY OF THE REGENERATE, AFFECTING THE PATTERN FORMATION. C) THE EFFECT OF CARCINOGENS ON LIMB REGENERATION IS STRICTLY LOCAL. D) CARCINOGENS MNNG AND 4NQO CAUSE PERMANENT CHANGES ON PATTERN FORMATION. E) THE TISSUES OF REGENERATING LIMBS AND THE TISSUES OF THE INTACT LIMB WHICH HAVE REGENERATING ABILITY SHOW INCREASED RESISTANCE TO THE EFFECTS OF CARCINOGENIC SUBSTANCES.","abstract_html":"THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL MORPHOLOGY OF THE REGENERATE, AFFECTING THE PATTERN FORMATION. C) THE EFFECT OF CARCINOGENS ON LIMB REGENERATION IS STRICTLY LOCAL. D) CARCINOGENS MNNG AND 4NQO CAUSE PERMANENT CHANGES ON PATTERN FORMATION. E) THE TISSUES OF REGENERATING LIMBS AND THE TISSUES OF THE INTACT LIMB WHICH HAVE REGENERATING ABILITY SHOW INCREASED RESISTANCE TO THE EFFECTS OF CARCINOGENIC SUBSTANCES.","abstract_has_math":false,"creators":["Ζηλάκος, Νικόλαος"],"institution":"Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:24:49Z","subjects":["AMPHIBIA","Carcinogenesis","LIMBREGENERATION","PATTERN FORMATION","Teratogenesis","ΑΝΑΓΕΝΝΗΣΗ ΑΚΡΩΝ ΑΜΦΙΒΙΩΝ","ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ","ΤΕΡΑΤΟΓΕΝΝΕΣΗ ΑΚΡΩΝ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1300"],"render_values":[{"text":"10.12681/eadd/1300","href":"https://doi.org/10.12681/eadd/1300","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1300","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ζηλάκος, Νικόλαος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["AMPHIBIA","Carcinogenesis","LIMBREGENERATION","PATTERN FORMATION","Teratogenesis","ΑΝΑΓΕΝΝΗΣΗ ΑΚΡΩΝ ΑΜΦΙΒΙΩΝ","ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ","ΤΕΡΑΤΟΓΕΝΝΕΣΗ ΑΚΡΩΝ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1300","http://hdl.handle.net/10442/hedi/1300"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL MORPHOLOGY OF THE REGENERATE, AFFECTING THE PATTERN FORMATION. C) THE EFFECT OF CARCINOGENS ON LIMB REGENERATION IS STRICTLY LOCAL. D) CARCINOGENS MNNG AND 4NQO CAUSE PERMANENT CHANGES ON PATTERN FORMATION. E) THE TISSUES OF REGENERATING LIMBS AND THE TISSUES OF THE INTACT LIMB WHICH HAVE REGENERATING ABILITY SHOW INCREASED RESISTANCE TO THE EFFECTS OF CARCINOGENIC SUBSTANCES.","Ο ΣΤΟΧΟΣ ΤΗΣ ΔΙΑΤΡΙΒΗΣ ΑΥΤΗΣ ΕΙΝΑΙ Η ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΚΑΡΚΙΝΟΓΟΝΩΝ ΧΗΜΙΚΩΝ ΟΥΣΙΩΝ ΣΕ ΑΝΑΓΕΝΝΩΜΕΝΑ ΚΑΙ ΑΘΙΚΤΑ ΑΚΡΑ ΕΝΗΛΙΚΩΝ ΟΥΡΟΔΕΛΩΝ ΑΜΦΙΒΙΩΝ ΤΟΥ ΕΙΔΟΥΣ TRITURUS CRISTATUS. ΓΙΑ ΤΗΝ ΕΠΙΤΕΥΞΗ ΤΟΥ ΣΤΟΧΟΥ, ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ ΧΟΡΗΓΗΘΗΚΑΝΣΕ ΤΡΙΑ ΔΙΑΦΟΡΕΤΙΚΑ ΣΤΑΔΙΑ ΤΗΣ ΑΝΑΓΕΝΝΗΣΗΣ ΤΩΝ ΑΚΡΩΝ 'Η ΧΟΡΗΓΗΘΗΚΑΝ ΣΕ ΑΘΙΚΤΑ ΑΚΡΑ. ΤΑ ΤΡΙΑ ΣΤΑΔΙΑ ΠΟΥ ΕΠΙΛΕΧΘΗΚΑΝ ΗΤΑΝ: ΣΤΑΔΙΟ ΕΠΟΥΛΩΣΗΣ ΤΗΣ ΠΛΗΓΗΣ (ΣΤΑΔΙΟ-Α), ΣΤΑΔΙΟ ΤΗΣ ΑΠΟΔΙΑΦΟΡΟΠΟΙΗΣΗΣ ΤΩΝ ΙΣΤΩΝ ΤΟΥ ΚΟΛΟΒΩΜΑΤΟΣ (ΣΤΑΔΙΟ-Β) ΚΑΙ ΣΤΑΔΙΟ ΤΟΥ ΝΕΑΡΟΥ 'Η ΠΡΟΧΩΡΗΜΕΝΟΥ ΚΩΝΟΥ (ΣΤΑΔΙΟ-Γ). ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ ΠΟΥ ΧΟΡΗΓΗΘΗΚΑΝ (10 -15 ΜGR) ΗΤΑΝ ΤΑ MNNG, 4NQO, DBA ΚΑΙ DMN. ΤΑ ΣΥΜΠΕΡΑΣΜΑΤΑ ΠΟΥ ΠΡΟΕΚΥΨΑΝ ΑΠΟ ΤΗ ΣΥΖΗΤΗΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΕΙΝΑΙ: Α) ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ ΚΑΘΥΣΤΕΡΟΥΝ ΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΟΤΑΝ ΧΟΡΗΓΗΘΟΥΝ ΣΤΟ ΣΤΑΔΙΟ Β 'Η Γ. Β) ΤΑ ΠΑΡΑΠΑΝΩ ΚΑΡΚΙΝΟΓΟΝΑ ΜΠΟΡΟΥΝ ΝΑ ΑΝΑΣΤΕΙΛΛΟΥΝ ΤΗΝ ΑΝΑΓΕΝΝΗΣΗ 'Η ΝΑ ΔΙΑΤΑΡΑΞΟΥΝ ΤΗ ΣΚΕΛΕΤΙΚΗ ΜΟΡΦΟΛΟΓΙΑ ΤΟΥ ΑΝΑΓΕΝΝΗΜΑΤΟΣ ΕΠΗΡΕΑΖΟΝΤΑΣ ΤΟ ΣΧΗΜΑΤΙΣΜΟ ΤΟΥ ΠΡΟΤΥΠΟΥ ΤΩΝ ΑΚΡΩΝ Γ) Η ΕΠΙΔΡΑΣΗΤΩΝ ΚΑΡΚΙΝΟΓΟΝΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΕΙΝΑΙ ΤΟΠΙΚΗ. Δ) ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ MNNG ΚΑΙ 4NQO ΕΠΙΦΕΡΟΥΝ ΜΟΝΙΜΗ ΑΛΛΑΓΗ ΣΤΟ ΣΧΗΜΑΤΙΣΜΟ ΤΟΥ ΠΡΟΤΥΠΟΥ ΤΩΝ ΑΚΡΩΝ. Ε) ΟΙΙΣΤΟΙ ΤΩΝ ΑΝΑΓΕΝΝΩΜΕΝΩΝ ΑΚΡΩΝ ΚΑΙ ΟΙ ΙΚΑΝΟΙ ΓΙΑ ΑΝΑΓΕΝΝΗΣΗ ΙΣΤΟΙ ΤΩΝ ΑΘΙΚΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ TRITURUS CRISTATUS ΠΡΟΒΑΛΛΟΥΝ ΜΕΓΑΛΗ ΑΝΤΙΣΤΑΣΗ ΣΤΙΣ ΕΠΙΔΡΑΣΕΙΣ ΤΩΝ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ."]},{"key":"dc:title","label":"Title","values":["ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS","THE EFFECT OF CARCINOGENS ON LIMB REGENERATION OF THE URODELE AMPHIBIAN TRITURUS CRISTATUS"]}]}],"canonical_facts":{"dc:creator":["Ζηλάκος, Νικόλαος"],"dc:date":["1990"],"dc:description":["THE MAIN AIM OF THIS RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND HEALING, STAGE B: DEDIFFERENTIATION AND STAGE C: EARLY OR LATE BLASTEMA STAGE. THE CARCINOGENIC SUBSTANCES THAT ADMINISTERED (10 -15 MGR) WERE: MNNG, 4NQO, DBA AND DMN. THE MAIN CONCLUSIONS DRAWN FROM THE RESULTS ARE: A) CARCINOGENS CAUSE DELAY TO LIMB REGENERATION WHEN THEY ARE ADMINISTERED AT STAGES B OR C. B) . THE ABOVE CARCINOGENS CAN INHIBIT THE REGENERATION OR DISTURB THE SCELETAL MORPHOLOGY OF THE REGENERATE, AFFECTING THE PATTERN FORMATION. C) THE EFFECT OF CARCINOGENS ON LIMB REGENERATION IS STRICTLY LOCAL. D) CARCINOGENS MNNG AND 4NQO CAUSE PERMANENT CHANGES ON PATTERN FORMATION. E) THE TISSUES OF REGENERATING LIMBS AND THE TISSUES OF THE INTACT LIMB WHICH HAVE REGENERATING ABILITY SHOW INCREASED RESISTANCE TO THE EFFECTS OF CARCINOGENIC SUBSTANCES.","Ο ΣΤΟΧΟΣ ΤΗΣ ΔΙΑΤΡΙΒΗΣ ΑΥΤΗΣ ΕΙΝΑΙ Η ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΚΑΡΚΙΝΟΓΟΝΩΝ ΧΗΜΙΚΩΝ ΟΥΣΙΩΝ ΣΕ ΑΝΑΓΕΝΝΩΜΕΝΑ ΚΑΙ ΑΘΙΚΤΑ ΑΚΡΑ ΕΝΗΛΙΚΩΝ ΟΥΡΟΔΕΛΩΝ ΑΜΦΙΒΙΩΝ ΤΟΥ ΕΙΔΟΥΣ TRITURUS CRISTATUS. ΓΙΑ ΤΗΝ ΕΠΙΤΕΥΞΗ ΤΟΥ ΣΤΟΧΟΥ, ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ ΧΟΡΗΓΗΘΗΚΑΝΣΕ ΤΡΙΑ ΔΙΑΦΟΡΕΤΙΚΑ ΣΤΑΔΙΑ ΤΗΣ ΑΝΑΓΕΝΝΗΣΗΣ ΤΩΝ ΑΚΡΩΝ 'Η ΧΟΡΗΓΗΘΗΚΑΝ ΣΕ ΑΘΙΚΤΑ ΑΚΡΑ. ΤΑ ΤΡΙΑ ΣΤΑΔΙΑ ΠΟΥ ΕΠΙΛΕΧΘΗΚΑΝ ΗΤΑΝ: ΣΤΑΔΙΟ ΕΠΟΥΛΩΣΗΣ ΤΗΣ ΠΛΗΓΗΣ (ΣΤΑΔΙΟ-Α), ΣΤΑΔΙΟ ΤΗΣ ΑΠΟΔΙΑΦΟΡΟΠΟΙΗΣΗΣ ΤΩΝ ΙΣΤΩΝ ΤΟΥ ΚΟΛΟΒΩΜΑΤΟΣ (ΣΤΑΔΙΟ-Β) ΚΑΙ ΣΤΑΔΙΟ ΤΟΥ ΝΕΑΡΟΥ 'Η ΠΡΟΧΩΡΗΜΕΝΟΥ ΚΩΝΟΥ (ΣΤΑΔΙΟ-Γ). ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ ΠΟΥ ΧΟΡΗΓΗΘΗΚΑΝ (10 -15 ΜGR) ΗΤΑΝ ΤΑ MNNG, 4NQO, DBA ΚΑΙ DMN. ΤΑ ΣΥΜΠΕΡΑΣΜΑΤΑ ΠΟΥ ΠΡΟΕΚΥΨΑΝ ΑΠΟ ΤΗ ΣΥΖΗΤΗΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΕΙΝΑΙ: Α) ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ ΚΑΘΥΣΤΕΡΟΥΝ ΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΟΤΑΝ ΧΟΡΗΓΗΘΟΥΝ ΣΤΟ ΣΤΑΔΙΟ Β 'Η Γ. Β) ΤΑ ΠΑΡΑΠΑΝΩ ΚΑΡΚΙΝΟΓΟΝΑ ΜΠΟΡΟΥΝ ΝΑ ΑΝΑΣΤΕΙΛΛΟΥΝ ΤΗΝ ΑΝΑΓΕΝΝΗΣΗ 'Η ΝΑ ΔΙΑΤΑΡΑΞΟΥΝ ΤΗ ΣΚΕΛΕΤΙΚΗ ΜΟΡΦΟΛΟΓΙΑ ΤΟΥ ΑΝΑΓΕΝΝΗΜΑΤΟΣ ΕΠΗΡΕΑΖΟΝΤΑΣ ΤΟ ΣΧΗΜΑΤΙΣΜΟ ΤΟΥ ΠΡΟΤΥΠΟΥ ΤΩΝ ΑΚΡΩΝ Γ) Η ΕΠΙΔΡΑΣΗΤΩΝ ΚΑΡΚΙΝΟΓΟΝΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΕΙΝΑΙ ΤΟΠΙΚΗ. Δ) ΤΑ ΚΑΡΚΙΝΟΓΟΝΑ MNNG ΚΑΙ 4NQO ΕΠΙΦΕΡΟΥΝ ΜΟΝΙΜΗ ΑΛΛΑΓΗ ΣΤΟ ΣΧΗΜΑΤΙΣΜΟ ΤΟΥ ΠΡΟΤΥΠΟΥ ΤΩΝ ΑΚΡΩΝ. Ε) ΟΙΙΣΤΟΙ ΤΩΝ ΑΝΑΓΕΝΝΩΜΕΝΩΝ ΑΚΡΩΝ ΚΑΙ ΟΙ ΙΚΑΝΟΙ ΓΙΑ ΑΝΑΓΕΝΝΗΣΗ ΙΣΤΟΙ ΤΩΝ ΑΘΙΚΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ TRITURUS CRISTATUS ΠΡΟΒΑΛΛΟΥΝ ΜΕΓΑΛΗ ΑΝΤΙΣΤΑΣΗ ΣΤΙΣ ΕΠΙΔΡΑΣΕΙΣ ΤΩΝ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ."],"dc:identifier":["10.12681/eadd/1300","http://hdl.handle.net/10442/hedi/1300"],"dc:language":["gre"],"dc:publisher":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"],"dc:subject":["AMPHIBIA","Carcinogenesis","LIMBREGENERATION","PATTERN FORMATION","Teratogenesis","ΑΝΑΓΕΝΝΗΣΗ ΑΚΡΩΝ ΑΜΦΙΒΙΩΝ","ΚΑΡΚΙΝΟΓΟΝΕΣ ΟΥΣΙΕΣ","ΤΕΡΑΤΟΓΕΝΝΕΣΗ ΑΚΡΩΝ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"dc:title":["ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS","THE EFFECT OF CARCINOGENS ON LIMB REGENERATION OF THE URODELE AMPHIBIAN TRITURUS CRISTATUS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:49Z"}