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Showing 1 to 20 of 82 for “"Carcinogens"”.
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
<p>The inhibitory effects of the two naturally occuning isothiocyanates, benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) on the metabolism and mutagenicity of 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster …
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Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens
<p>The environmental carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause …
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The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth
… moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive incorporation of C<sup>14</sup>-labeled choline and ethanolamine into PC and PE, respectively, were done. In general, there was a decrease in the saturated fatty acid …
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Investigation Into The Binding Interactions Of Klenow Fragment To Dna Modified With Carcinogens Af And Aaf Using Surface Plasmon Resonance
<p>The two major forms of DNA adducts from the carcinogen N-acetoxyacetyl-2-aminofluorene, N-(deoxygunanonsin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) and N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF), are both known to impede replication, though in different ways. AAF is a strong block to …
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ΕΠΙΔΡΑΣΗ ΚΑΡΚΙΝΟΓΟΝΩΝ ΟΥΣΙΩΝ ΣΤΗΝ ΑΝΑΓΕΝΝΗΣΗ ΤΩΝ ΑΚΡΩΝ ΤΟΥ ΟΥΡΟΔΕΛΟΥΣ ΑΜΦΙΒΙΟΥ TRITURUS CRISTATUS
… RESEARCH IS THE STUDY OF THE EFFECTS OF CHEMICAL CARCINOGENS ON INFACT AND REGENERATING LIMBS OF ADULT TRITURUS CRISTATUS (AMPHIBIA URODELA). CARCINOGENIC SUBSTANCES WERE ADMINISTERED TO INTACT OR REGENERATING LIMBS,THE LAST BEING IN THREE REGENERATIVE STAGES CHOSEN AS FOLLOWS: STAGE A: WOUND …
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Association between Air Pollution and Cancer Incidence by region
… rates increase and to find out the influence of carcinogens on cancer incidence. METHODS: This study carried out the examination of relation between cancer incidence and air pollutants through ecologic study. Also the influence of carcinogens on cancer incidence were analyzed by risk assessment …
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The Effect of the Carcinogen 20-methylcholanthrene on the Production of Vaccinal Viral Lesions on the Chorio-Allantoic Membrane of the Embryonated Egg
… were devoted to observing the effect of certain carcinogens In relation to those viruses which had the ability to produce tumorous growths in experimental animals. It has been shown that these animals, pretreated with certain carcinogens, which included 20-methylcholánthrene, exhibited marked …
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Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice
… including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts present in a tissue …
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Preparation of Immunogens and Antisera Monitoring for Eventual Radioimmunoassay Development of Benzidine.
… and Health and determined to be potential human carcinogens. Several studies show that benzidine-based dyes are associated with animal disease states and human bladder cancer.
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Evaluation of the induction of rat hepatic and pancreatic glutathione S-transferases by treatment with the cruciferous nitrile, cyanohydroxybutene
… are believed to provide protection against carcinogens by inducing detoxifying including the glutathione S-transferase isoenzymes (GSTs). The GSTs catalyze the conjugation of glutathione (GSH) to electrophilic xenobiotics. As peroxidases, they detoxify organic hydroperoxides. Each isoenzyme …
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THE ROLE OF ACTIVE AND ACTIVE-SITE ALKYLATED HUMAN O6-METHYLGUANINE-DNA METHYTRANSFERASE (MGMT AND R-MGMT) IN DNA REPAIR AND BIOMONITORING
… cells against the mutagenic effect of alkylating carcinogens, was found to be localised in the nucleus (except the nucleolus) by immunofluorescence staining using polyclonal and monoclonal antibodies. The supporting experiments came from differential staining of the GMT-deficient (mer-) and …
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Advancing Toxicology-Based Cancer Risk Assessment with Informatics
Since exposure to carcinogens can occur in the environment from various point sources, cancer risk assessment attempts to define and limit potential exposure such that the risk of developing cancer is negligible. While cancer risk assessment is widely used with certain methodologies well accepted …
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Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
… greatly the detoxification of tobacco-related carcinogens in vivo, and may therefore have an important role in determining susceptibility to oesophageal cancer.
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Variability and Uncertainty in Risk Estimation for Brownfields Redevelopment
… methods is increasing. Contaminant data for non-carcinogens and carcinogens from 21 brownfields sites in Pennsylvania were collected and compiled. These were used to evaluate the performance of the deterministic and several probabilistic methods for assessing exposure and risk in relation to …
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Relationship between Industry and Occupation with Cancer Using the Illinois BRFSS Survey (2018 to 2022)
… 1), probable (Group 2A), or possible (Group 2B) carcinogens. Multiple logistic regression models were conducted, considering complex survey design and adjusting for demographic, socioeconomic, and lifestyle factors. A comprehensive case analysis was performed on a final sample of 10,503 …
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The association between air pollution and lung cancer in the north west of Adelaide: a case control study and air quality monitoring.
… and conditional logistic regression. Ambient carcinogens and fine particulates with potential industrial sources in the region were monitored in five locations. In the final multivariate model leaving school early, pack- years of cigarettes and not living in close proximity to the power …
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The effect of legislation concerning environmental tobacco smoke (ETS) on the short-term health of hospitality workers: A Canada – Italy comparison
… over 4000 chemicals many of them being known carcinogens and toxins. The recently-identified hazards of ETS have resulted in the implementation of new legislation to protect non-smokers’ health in jurisdictions worldwide. Purpose: This study tests the hypothesis that legislation eliminating …
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The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice
… To determine the effect of exposure to exogenous carcinogens on homologous recombination, FYDR mice were treated with two different chemotherapeutic agents, cisplatin and mitomycin-C.
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