Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 373 for “"Carcinogenesis"”.
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Mechanisms of trichloroacetic acid carcinogenesis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Estrogen receptor beta modulates prostate carcinogenesis
… progression. Estrogen is essential for prostate carcinogenesis with evidence from epidemiological, in vitro, human tissue and animal studies. Most suggests that estrogen receptor beta (ERβ) is tumour-suppressive, but trials of ERβ-selective agents have not improved clinical outcomes. ERβ has also …
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Effects of Radiation Exposure on Lung Carcinogenesis
… fractionated or acute radiation exposure on lung carcinogenesis in vivo were determined utilizing the transgenic LA1 K-ras mouse model of lung cancer compared to wildtype littermates. Radiation-induced carcinogenesis is a major concern not only for cancer patients being treated with therapeutic …
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Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis
… into the host genome is a key event in cervical carcinogenesis, with oxidative stress (OS) likely playing a major role in promoting DNA damage, and subsequently, integration. In our current study, we demonstrated a chain of events leading from the induction of OS, to DNA damage, and then to viral …
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Role of Spz1 in HPV-mediated carcinogenesis
… the cell and investigate its role in HPV-induced carcinogenesis through its interaction with E7. To achieve this, HaCaT and NIH3T3-derived cell lines stably overexpressing HPV-16 E7 and/or Spz1 were generated to study the effect of Spz1 on E7-induced transformation of cells in vitro. Cells …
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Heat stress: A risk factor for skin carcinogenesis
… radiation (UV) is a major risk factor for skin carcinogenesis. UV, particularly the UVB spectrum, causes formation of cyclobutane pyrimidine dimers (CPD) in cellular DNA. Persistent and incorrectly repaired CPDs lead to DNA mutations and consequently, formation of cutaneous lesions. …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
Kidneys are important target organ for oxidative stress mediated injury and oxidative stress has been suggested as a common pathway shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our …
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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
<p>Cervical cancer (CxCa) remains the fourth leading cause of cancer related deaths among women worldwide. Cervical cancer is mainly (~ 99.7%) derived from high risk Human papillomavirus (HR HPV). HPV E6/E7 are the two main oncoproteins that interfere with p53 and pRb (retinoblastoma) cell cycle …
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Causes and Consequences of Genomic Instability in Prostatic Carcinogenesis
… nature of barriers to the evolution of prostatic carcinogenesis such as oncogene- and telomere-induced senescence that may be exploited for therapeutic gain. These understandings may also help tailor management for prostate cancer such as risk stratification for men with HPIN and the use of …
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The role of Mullerian differentiation in epithelial ovarian carcinogenesis
Ovarian cancer is a fatal disease because of the lack of symptoms and markers for early detection. Most ovarian neoplasms resemble and are classified according to the complex characteristics of Mullerian duct epithelia. We tested the hypothesis that Mullerian epithelial characteristics influence …
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Cell senescence and aging in carcinogenesis and liver repopulation
… similar biological mechanisms, such that carcinogenesis and liver repopulation represent in fact “two sides of the same coin”, as it has been proposed. Given the similarities of biological responses between the RS-treated and the aged liver, we then probed into possible cellular and …
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Dietary Influences on Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis
Made available in DSpace on 2015-05-13T15:26:58Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7913412.PDF: 6860257 bytes, checksum: f4ebce04061d1ca88e5e4b73e6c41ef8 (MD5) Previous issue date: 1978
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Somatic variation, carcinogenesis and cancer risk in the lung
Somatic evolution is the driving force behind carcinogenesis, a principle recently underscored by discoveries in normal tissue. These discoveries have highlighted an underappreciated diversity of somatic mosaicism within every tissue and across individuals. Human tissue comprises thousands of …
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Prediction of nitric oxide concentrations during inflammation and carcinogenesis
… of NO in inflamed tissues or during carcinogenesis are largely unknown. The objective of the research in this thesis was to predict NO concentrations in an inflamed colon and a cutaneous metastatic melanoma, two areas where NO has been implicated in the development or progression of …
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed to a single tumourigenic dose (50 mg/kg) of AFB1. Neither ogg1 …
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Investigating the Effects of Particle Radiation Exposure on Lung Carcinogenesis
Lung cancer accounts for more cancer-related deaths than any other cancer type among both men and women. The overall increase in radiation risk for human cancer types has been substantiated by the epidemiological data obtained from atomic bomb survivors and uranium mine workers. The lung has a …
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… UV response of the skin and during UV-induced carcinogenesis is not known. We hypothesize that the UV-induced activation of Erbb2 increases skin tumorigenesis. To test this hypothesis and determine the mechanisms through which Erbb2 acts, the following specific aims were investigated: 1. …
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