ΜΕΛΕΤΗ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΣΤΗΝ ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ: ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΜΟΡΙΟΥ

HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. PROGESTERONE RECEPTOR HAS BEEN STUDIED FOR PROGESTERONE SPECIFICITY AS COMPARED TO OTHER STEROID HORMONES AND RELATIVE PARAMETERS WERE DETERMINED. ANALYTICAL METHODS DEMONSTRATE THAT PROGESTERONE RECEPTOR SEEMS TO BE A TETRAMER(8-9S) WHICH IS DIVIDED INTO PARTS OF LOWER MOLECULAR WEIGHT, POSSIBLE DIMERS, MONOMERS OR MERORECEPTORS, BECAUSE OF PROTEOLYSIS OR PHYSIOLOGICAL MODIFICATION (TRANSFORMATION). THE NUCLEAR PROGESTERONE RECEPTOR HAS BEEN SHOWN TO HAVE THE SAME CHARACTERISTICS AS THE CYTOPLASTIC IN VIVO TRANSFORMED RECEPTOR. RECEPTOR PURIFICATION SHOWS PROTEINS OF DIFFERENT MOLECULAR WEIGHTS RANGE 120000 TO 30000.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1987

Author dc:creator

• Λεβεντάκου, Αθηνά

• Καθαρισμός
• Προγεστερόνη
• Υποδοχέας
• Χαρακτηρισμοί
• Characterizations
• Progesterone
• Purification
• Receptors
• Φυσικές Επιστήμες
• Βιολογία
• Natural Sciences
• Biological Sciences

Language dc:language

gre

Identifier

10.12681/eadd/0471

OAI identifier oai:identifier

oai:10442/0471