Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3622 for “"Receptors"”.
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Nuclear Receptors in Lung Cancer
… cognate ligand treatment for selected nuclear receptors. In addition, the NR profiles of 30 microdissected and pair-matched patient tissue samples provided a subset of NRs showing dramatic differences in expression and subgroupings that demonstrate individual variations between the normal and …
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Dipyrromethane based receptors for anions
… the synthesis of a range of dipyrromethane based receptors and their ability to bind anions, in particular carboxylates of amino acid derivatives.<br/>Chapter I provides a general introduction to the field of Supramolecular Chemistry and its applications. In this chapter a series of receptors for …
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Inflammation, kinins, and kinin receptors
… in the regulation of kinins and their receptors in different settings of inflammation. It is known that BK is generated in the airways of asthmatic subjects and that disease symptoms are exacerbated during respiratory viral infections. In paper I, we report that BK induces an …
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DNA Bending by Steroid Receptors
… occupied ER. Constitutively active mutant receptors had directed DNA bending angles similar to estrogen occupied WT ER. These findings imply that transcriptionally active mutant ERs induce directed bending angles that are similar to the DNA bend induced by WT ER.
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Characterisation of protease activated receptors
The thrombin receptor is a seven transmembrane G-protein-coupled receptor that is activated by thrombin cleavage. In order to characterise the thrombin receptor three mouse monoclonal antibodies were isolated by using a recombinant fusion protein incorporating the extracellular domain of the human …
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Receptor activation in GNRH receptors
Includes bibliographical references.
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Formylated dipyrromethane based phosphate derivatives receptors
… effort to design, synthesize, and study various receptors that were intended to overcome those challenges. In Chapter 1, a brief introduction to anion binding chemistry is provided with a particular focus on phosphate anion recognition. The common defining feature of the receptors reviewed is the …
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Ryanodine receptors in calcium signaling pathways
… being highly toxic.</p><p>Ryanodine receptors (RyRs) and inositol trisphosphate receptors (IP<sub>3</sub>Rs) are Ca<sup>2+</sup> -release channels located on intracellular membranes of the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that perform essential functions as key …
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Formylated dipyrromethane based phosphate derivatives receptors
… effort to design, synthesize, and study various receptors that were intended to overcome those challenges. In Chapter 1, a brief introduction to anion binding chemistry is provided with a particular focus on phosphate anion recognition. The common defining feature of the receptors reviewed is the …
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Odorant receptors: regulation, signaling, and expression
… of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This signaling cascade comprises the primary olfactory response. …
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Polymorphisms in heat shock protein receptors
Das extrazelluläre Hitzeschockprotein 70 (Heat Shock Protein 70, HSP70) kann als immunologisches Gefahrensignal fungieren und stimuliert die Aktivität zytotoxischer T-Lymphozyten und natürlicher Killerzellen. In diesem Kontext stellt HSP70 ein vielversprechendes Werkzeug im Rahmen immunologischer …
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Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …
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Developing Antibody Tools against Glycine Receptors
[Restricted]
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Functional Analysis of Plant Glutamate Receptors
The plant glutamate receptors (GLRs) are homologs of mammalian ionotropic glutamate receptors (iGluRs) and are hypothesized to be potential amino acid sensors in plants. Since their first discovery in 1998, the members of plant GLRs have been implicated in diverse processes such as C/N ratio …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… Modulate Cellular Activity of Ryanodine Receptors. Doctor of Philosophy (Biomedical Sciences), December, 2012, 160 pp., 7 tables, 39 figures, bibliography 241 titles. Ryanodine Receptors (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs …
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Localization of FC Receptors on Murine Spermatozoa.
Studies on the localization of acrosomal enzymes have shown that a heat stable component in non-immune serum binds to the acrosomal region of spermatozoa of a number of species (Weil and Finkler, 1959; Edwards, 1960). Beck et al. (1962) demonstrated by immunofluorescent techniques that this serum …
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Calix[4]pyrrole-based ion pair receptors
Compared with simple ion receptors, ion pair receptors display significantly enhanced affinity to ions through allosteric effects and additional electrostatic interactions between the bound ions, as well as host-guest interactions. Taken in concert, these necessarily permit a higher level of …
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Structure-Function Analysis of Insect Olfactory Receptors
… ORs, both of which are G protein coupled receptors (GPCRs), whose activation leads to increased concentrations of intracellular second messengers and opening of cyclic nucleotide-gated channels (CNG; Buck and Axel, 1991; Colbert et al., 1997; Firestein et al., 1991; Nakamura and Gold, …
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