{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0471"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0471","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΣΤΗΝ ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ: ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΜΟΡΙΟΥ","abstract":"HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. PROGESTERONE RECEPTOR HAS BEEN STUDIED FOR PROGESTERONE SPECIFICITY AS COMPARED TO OTHER STEROID HORMONES AND RELATIVE PARAMETERS WERE DETERMINED. ANALYTICAL METHODS DEMONSTRATE THAT PROGESTERONE RECEPTOR SEEMS TO BE A TETRAMER(8-9S) WHICH IS DIVIDED INTO PARTS OF LOWER MOLECULAR WEIGHT, POSSIBLE DIMERS, MONOMERS OR MERORECEPTORS, BECAUSE OF PROTEOLYSIS OR PHYSIOLOGICAL MODIFICATION (TRANSFORMATION). THE NUCLEAR PROGESTERONE RECEPTOR HAS BEEN SHOWN TO HAVE THE SAME CHARACTERISTICS AS THE CYTOPLASTIC IN VIVO TRANSFORMED RECEPTOR. RECEPTOR PURIFICATION SHOWS PROTEINS OF DIFFERENT MOLECULAR WEIGHTS RANGE 120000 TO 30000.","abstract_html":"HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. PROGESTERONE RECEPTOR HAS BEEN STUDIED FOR PROGESTERONE SPECIFICITY AS COMPARED TO OTHER STEROID HORMONES AND RELATIVE PARAMETERS WERE DETERMINED. ANALYTICAL METHODS DEMONSTRATE THAT PROGESTERONE RECEPTOR SEEMS TO BE A TETRAMER(8-9S) WHICH IS DIVIDED INTO PARTS OF LOWER MOLECULAR WEIGHT, POSSIBLE DIMERS, MONOMERS OR MERORECEPTORS, BECAUSE OF PROTEOLYSIS OR PHYSIOLOGICAL MODIFICATION (TRANSFORMATION). THE NUCLEAR PROGESTERONE RECEPTOR HAS BEEN SHOWN TO HAVE THE SAME CHARACTERISTICS AS THE CYTOPLASTIC IN VIVO TRANSFORMED RECEPTOR. RECEPTOR PURIFICATION SHOWS PROTEINS OF DIFFERENT MOLECULAR WEIGHTS RANGE 120000 TO 30000.","abstract_has_math":false,"creators":["Λεβεντάκου, Αθηνά"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:17Z","subjects":["Καθαρισμός","Προγεστερόνη","Υποδοχέας","Χαρακτηρισμοί","Characterizations","Progesterone","Purification","Receptors","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0471"],"render_values":[{"text":"10.12681/eadd/0471","href":"https://doi.org/10.12681/eadd/0471","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0471","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Λεβεντάκου, Αθηνά"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Καθαρισμός","Προγεστερόνη","Υποδοχέας","Χαρακτηρισμοί","Characterizations","Progesterone","Purification","Receptors","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0471","http://hdl.handle.net/10442/hedi/0471"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. PROGESTERONE RECEPTOR HAS BEEN STUDIED FOR PROGESTERONE SPECIFICITY AS COMPARED TO OTHER STEROID HORMONES AND RELATIVE PARAMETERS WERE DETERMINED. ANALYTICAL METHODS DEMONSTRATE THAT PROGESTERONE RECEPTOR SEEMS TO BE A TETRAMER(8-9S) WHICH IS DIVIDED INTO PARTS OF LOWER MOLECULAR WEIGHT, POSSIBLE DIMERS, MONOMERS OR MERORECEPTORS, BECAUSE OF PROTEOLYSIS OR PHYSIOLOGICAL MODIFICATION (TRANSFORMATION). THE NUCLEAR PROGESTERONE RECEPTOR HAS BEEN SHOWN TO HAVE THE SAME CHARACTERISTICS AS THE CYTOPLASTIC IN VIVO TRANSFORMED RECEPTOR. RECEPTOR PURIFICATION SHOWS PROTEINS OF DIFFERENT MOLECULAR WEIGHTS RANGE 120000 TO 30000.","Ο ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΕΙΝΑΙ Ο ΡΥΘΜΙΣΤΗΣ ΤΗΣ ΔΡΑΣΗΣ ΤΗΣ ΟΡΜΟΝΗΣ ΣΤΑ ΟΡΓΑΝΑ-ΣΤΟΧΟΥΣ ΠΤΗΝΩΝ ΚΑΙ ΘΗΛΑΣΤΙΚΩΝ. Η ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ ΕΙΝΑΙ ΙΣΤΟΣ-ΣΤΟΧΟΣ ΤΗΣ ΟΡΜΟΝΗΣ ΑΛΛΑ ΚΑΙ ΠΛΟΥΣΙΟΣ ΣΕ ΠΡΩΤΕΟΛΥΤΙΚΑ ΕΝΖΥΜΑ. Ο ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΜΕΛΕΤΗΘΗΚΕ ΩΣ ΠΡΟΣ ΤΗΝ ΑΠΟΛΥΤΗ ΕΞΕΙΔΙΚΕΥΣΗ ΤΟΥ ΓΙΑ ΤΗΝ ΟΡΜΟΝΗ ΑΥΤΗ ΚΑΙ ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ ΟΙ ΠΑΡΑΜΕΤΡΟΙ ΠΟΥ ΚΑΘΟΡΙΖΟΥΝ ΤΟ ΣΥΜΠΛΟΚΟ ΟΡΜΟΝΗΣ-ΥΠΟΔΟΧΕΑ. ΜΕ ΣΕΙΡΑ ΑΝΑΛΥΤΙΚΩΝ ΜΕΘΟΔΩΝ Ο ΥΠΟΔΟΧΕΑΣ ΦΑΙΝΕΤΑΙ ΟΤΙ ΕΧΕΙ ΜΙΑ ΑΡΧΙΚΗ ΔΟΜΗ 8-9S (ΤΕΤΡΑΜΕΡΕΣ) ΠΟΥ ΟΜΩΣ ΛΟΓΩ ΠΡΩΤΕΟΛΥΣΗΣ 'Η ΚΑΙ ΦΥΣΙΟΛΟΓΙΚΗΣ ΔΡΑΣΗΣ (ΜΕΤΑΣΧΗΜΑΤΙΣΜΟΣ) ΑΠΟΙΚΟΔΟΜΕΙΤΑΙ ΣΕ ΧΑΜΗΛΟΤΕΡΟΥ ΜΟΡΙΑΚΟΥ ΒΑΡΟΥΣ ΜΟΡΦΕΣ (ΔΙΜΕΡΗ 6-7S, ΜΟΝΟΜΕΡΗ 4S ΚΑΙ ΜΕΡΟΥΠΟΔΟΧΕΙΣ 2-3S). Ο ΠΥΡΗΝΙΚΟΣ ΥΠΟΔΟΧΕΑΣ ΤΩΝ ΚΥΤΤΑΡΩΝ ΤΗΣ ΜΗΤΡΑΣ ΕΧΕΙ ΤΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΟΥ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΟΥ IN VIVO ΥΠΟΔΟΧΕΑ, ΕΝΩ Η ΜΕΛΕΤΗ ΤΟΥ ΜΕ ΘΕΡΜΑΝΣΗ ΔΕΙΧΝΕΙ ΟΤΙ Ο ΥΠΟΔΟΧΕΑΣ ΑΠΟΙΚΟΔΟΜΕΙΤΑΙ ΣΕ ΧΑΜΗΛΟΥ ΜΟΡΙΑΚΟΥ ΒΑΡΟΥΣ ΜΟΡΦΕΣ. ΑΠΟ ΤΟΝ ΚΑΘΑΡΙΣΜΟ ΤΟΥ ΠΡΟΚΥΠΤΟΥΝ ΠΡΩΤΕΙΝΕΣ ΜΕ ΜΟΡΙΑΚΑ ΒΑΡΗ 120000 - 30000."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΣΤΗΝ ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ: ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΜΟΡΙΟΥ","PROGESTERON RECEPTON IN HUMAN UTERUS: CHARACTERIZATION AND PURIFICATION"]}]}],"canonical_facts":{"dc:creator":["Λεβεντάκου, Αθηνά"],"dc:date":["1987"],"dc:description":["HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. PROGESTERONE RECEPTOR HAS BEEN STUDIED FOR PROGESTERONE SPECIFICITY AS COMPARED TO OTHER STEROID HORMONES AND RELATIVE PARAMETERS WERE DETERMINED. ANALYTICAL METHODS DEMONSTRATE THAT PROGESTERONE RECEPTOR SEEMS TO BE A TETRAMER(8-9S) WHICH IS DIVIDED INTO PARTS OF LOWER MOLECULAR WEIGHT, POSSIBLE DIMERS, MONOMERS OR MERORECEPTORS, BECAUSE OF PROTEOLYSIS OR PHYSIOLOGICAL MODIFICATION (TRANSFORMATION). THE NUCLEAR PROGESTERONE RECEPTOR HAS BEEN SHOWN TO HAVE THE SAME CHARACTERISTICS AS THE CYTOPLASTIC IN VIVO TRANSFORMED RECEPTOR. RECEPTOR PURIFICATION SHOWS PROTEINS OF DIFFERENT MOLECULAR WEIGHTS RANGE 120000 TO 30000.","Ο ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΕΙΝΑΙ Ο ΡΥΘΜΙΣΤΗΣ ΤΗΣ ΔΡΑΣΗΣ ΤΗΣ ΟΡΜΟΝΗΣ ΣΤΑ ΟΡΓΑΝΑ-ΣΤΟΧΟΥΣ ΠΤΗΝΩΝ ΚΑΙ ΘΗΛΑΣΤΙΚΩΝ. Η ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ ΕΙΝΑΙ ΙΣΤΟΣ-ΣΤΟΧΟΣ ΤΗΣ ΟΡΜΟΝΗΣ ΑΛΛΑ ΚΑΙ ΠΛΟΥΣΙΟΣ ΣΕ ΠΡΩΤΕΟΛΥΤΙΚΑ ΕΝΖΥΜΑ. Ο ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΜΕΛΕΤΗΘΗΚΕ ΩΣ ΠΡΟΣ ΤΗΝ ΑΠΟΛΥΤΗ ΕΞΕΙΔΙΚΕΥΣΗ ΤΟΥ ΓΙΑ ΤΗΝ ΟΡΜΟΝΗ ΑΥΤΗ ΚΑΙ ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ ΟΙ ΠΑΡΑΜΕΤΡΟΙ ΠΟΥ ΚΑΘΟΡΙΖΟΥΝ ΤΟ ΣΥΜΠΛΟΚΟ ΟΡΜΟΝΗΣ-ΥΠΟΔΟΧΕΑ. ΜΕ ΣΕΙΡΑ ΑΝΑΛΥΤΙΚΩΝ ΜΕΘΟΔΩΝ Ο ΥΠΟΔΟΧΕΑΣ ΦΑΙΝΕΤΑΙ ΟΤΙ ΕΧΕΙ ΜΙΑ ΑΡΧΙΚΗ ΔΟΜΗ 8-9S (ΤΕΤΡΑΜΕΡΕΣ) ΠΟΥ ΟΜΩΣ ΛΟΓΩ ΠΡΩΤΕΟΛΥΣΗΣ 'Η ΚΑΙ ΦΥΣΙΟΛΟΓΙΚΗΣ ΔΡΑΣΗΣ (ΜΕΤΑΣΧΗΜΑΤΙΣΜΟΣ) ΑΠΟΙΚΟΔΟΜΕΙΤΑΙ ΣΕ ΧΑΜΗΛΟΤΕΡΟΥ ΜΟΡΙΑΚΟΥ ΒΑΡΟΥΣ ΜΟΡΦΕΣ (ΔΙΜΕΡΗ 6-7S, ΜΟΝΟΜΕΡΗ 4S ΚΑΙ ΜΕΡΟΥΠΟΔΟΧΕΙΣ 2-3S). Ο ΠΥΡΗΝΙΚΟΣ ΥΠΟΔΟΧΕΑΣ ΤΩΝ ΚΥΤΤΑΡΩΝ ΤΗΣ ΜΗΤΡΑΣ ΕΧΕΙ ΤΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΟΥ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΟΥ IN VIVO ΥΠΟΔΟΧΕΑ, ΕΝΩ Η ΜΕΛΕΤΗ ΤΟΥ ΜΕ ΘΕΡΜΑΝΣΗ ΔΕΙΧΝΕΙ ΟΤΙ Ο ΥΠΟΔΟΧΕΑΣ ΑΠΟΙΚΟΔΟΜΕΙΤΑΙ ΣΕ ΧΑΜΗΛΟΥ ΜΟΡΙΑΚΟΥ ΒΑΡΟΥΣ ΜΟΡΦΕΣ. ΑΠΟ ΤΟΝ ΚΑΘΑΡΙΣΜΟ ΤΟΥ ΠΡΟΚΥΠΤΟΥΝ ΠΡΩΤΕΙΝΕΣ ΜΕ ΜΟΡΙΑΚΑ ΒΑΡΗ 120000 - 30000."],"dc:identifier":["10.12681/eadd/0471","http://hdl.handle.net/10442/hedi/0471"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["Καθαρισμός","Προγεστερόνη","Υποδοχέας","Χαρακτηρισμοί","Characterizations","Progesterone","Purification","Receptors","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"dc:title":["ΜΕΛΕΤΗ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΣΤΗΝ ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ: ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΜΟΡΙΟΥ","PROGESTERON RECEPTON IN HUMAN UTERUS: CHARACTERIZATION AND PURIFICATION"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:17Z"}