Entry of feline infectious peritonitis virus in blood monocytes

Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the development of new therapeutic agents. However, little is known about the entry of FIPV. It is even questioned if the virus enters cells via direct fusion with the plasma membrane or after receptor-mediated internalization. In this thesis, the entry process of FIPV is studied to add upon the knowledge in FIPV pathogenesis and to evaluate the presence of possible targets for antiviral therapy.

Grantor dc:publisher

Ghent University. Faculty of Veterinary Medicine

Year dc:date

2009

Author dc:creator

• Van Hamme, Evelien

Contributors dc:contributor

• Nauwynck, Hans
• Dewerchin, Hannah

• Veterinary Sciences
• coronavirus
• virus entry
• feline infectious peritonitis virus
• monocytes
• receptors
• internalization pathway

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://biblio.ugent.be/publication/758320
urn:isbn:9789058641847
https://biblio.ugent.be/publication/758320/file/4335051

OAI identifier oai:identifier

oai:archive.ugent.be:758320