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Showing 1 to 20 of 400 for “"monocytes"”.
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TNFalpha expression in monocytes/macrophages
The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor …
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Functional Education of Monocytes During Infection
Tissue-infiltrating Ly6Chi monocytes play important protective roles during infection, including inflammatory cytokine secretion and pathogen killing. Here we show that during acute gastrointestinal infection with the protozoan parasite Toxoplasma gondii, recruited monocytes not only contributed to …
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Role of Monocytes and Neutrophils in Thrombosis
… interact closely with leukocytes such as monocytes and neutrophils and modify their activity. This thesis aims to identify novel mechanisms through which leukocytes and platelet-leukocyte interactions might contribute to thrombosis. The thesis focused on rapid interactions between these …
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Active Inhibition of T Cell Proliferation by Monocytes
<p>Monoclonal antibodies (mAb) to MHC class II molecules (anti-class II mAb) have been well described in their ability to inhibit T cell activation. The most current model is that anti-class II mAb interfere directly with the T cell receptor-major histocompatibility complex crosslinking which is …
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Recruitment of monocytes to the pre-ovulatory ovary
… ovary. We identified a specific population of monocytes, deemed ly6c^high monocytes, which infiltrate the ovary at a specific time. Immediately before ovulation occurs, ly6c^high monocytes are found in increased numbers in the ovaries, possibly to promote inflammation and follicular rupture. …
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The Interaction of Neisseria Gonorrhoeae with Human Monocytes
The ability of human monocytes to phagocytize and kill nonpiliated opaque (T3) and transparent (T4) gonococci was investigated in a tumbling tube suspension assay. A serum-sensitive strain, F62, and a serum-resistant strain, FA19, were studied. Viable colony-forming units remaining after incubation …
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INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES
Sepsis is serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however …
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Reversal of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease
… inflammation. Unlike microglia in late stage AD, monocytes retain the ability to clear Tau assemblies, but also secrete inflammatory cytokines. We propose the novel concept of chimeric scavenger receptors (CSR) that facilitate clearance of o-Tau while limiting proinflammatory responses in …
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Entry of feline infectious peritonitis virus in blood monocytes
Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To …
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Regulation of TIM-3 Expression in Mast cells and Monocytes
T cell immunoglobulin mucin domain 3 (TIM-3) which is a type-I membrane protein, is expressed on differentiated Th1 cell, mast cell and monocyte. Although expression of TIM-3 and its ligand galectin-9 has been demonstrated in mast cells, the transcriptional regulation of these molecules has not …
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Monocytes as Gene Therapy Vectors for the Treatment of Alzheimer’s Disease
… progression. Studies implicating the homing of monocytes to regions of CNS damage have led to the idea that it may be possible to use genetically modified monocytes to carry exogenous genes of interest into the brain or other organs for the purposes of gene therapy. To determine the time course …
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Regulation of HIV latency dynamics in monocytes and monocyte-derived macrophages
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Effects of Linoleic Acid on Tether Formation between Monocytes and Endothelial Cells
… atherosclerotic plaque development. Treatment of monocytes with linoleic acid leads to an increase in monocyte adhesion to endothelial cells under flow conditions; however, the mechanisms through which linoleic acid affect monocyte adhesion remain unclear. Using a combination of micropipette …
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Modulation of Brain Inflammation Induced by Interaction between Astrocytes, Neutrophils and Monocytes
… 18 B. Interaction between astrocytes and monocytes 20 1. Effect of THP1 cells on morphology of astrocytes 20 2. Effect of THP1 cells on inflammatory responses of astrocytes 24 3. Migration assay 26 4. Dose-dependent effect of TCM 29 5. Astrocytes regulate inflammatory responses in THP1 …
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Placental co-culture model reveals Listeria monocytogenes utilization of monocytes for vertical transmission
… with L. monocytogenes. Model exposure to monocytes infected with L. monocytogenes resulted in an increase in sICAM-1 expression (~3-fold) and an increase in cell cytotoxicity by ~20%. Immunostaining of co-culture models exposed to L. monocytogenes-infected monocytes revealed severe …
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Chloride Channels in Normal Human Blood Monocytes and a Macrophage-like Cell Line
… A major class of phagocytic cells is composed of monocytes and macrophages. During inflammation there is release of several inflammatory mediators and chemokines, which attract circulating monocytes towards the endothelium. Monocytes firmly adhere to, and actively migrate through, endothelial …
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Differential Stimulation of Monocytes to Secrete Secretory Leukocyte Protease Inhibitor by Lipopolysaccharide of Periodontal Pathogens
… and inflammatory systems, including macrophages, monocytes, and endothelial cells, and contributes to systemic changes known as septic shock. Each LPS molecule has three regions: oligosaccharide, core, and lipid A. Oligosaccharide is exposed on the cell surface, and lipid A anchors LPS in the …
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Effect of viral and host genetics on pcv2 replication in lymphoblasts and clearance by monocytes
Porcine circovirus type 2 (PCV2), a very small, circular, single-stranded DNA virus, is the major etiologic agent of porcine circovirus-associated diseases (PCVADs) and is widely prevalent in swine herds. It causes significant economic losses to the global pig industry. Three major PCV2 genotypes …
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