{"id":{"repo_id":"ghent","oai_identifier":"oai:archive.ugent.be:758320"},"canonical_url":"https://search.dev.ndltd.org/etd/ghent/oai:archive.ugent.be:758320","repository":{"repo_id":"ghent","name":"Ghent University","base_url":"https://biblio.ugent.be/oai"},"display":{"title":"Entry of feline infectious peritonitis virus in blood monocytes","abstract":"Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the development of new therapeutic agents. However, little is known about the entry of FIPV. It is even questioned if the virus enters cells via direct fusion with the plasma membrane or after receptor-mediated internalization. In this thesis, the entry process of FIPV is studied to add upon the knowledge in FIPV pathogenesis and to evaluate the presence of possible targets for antiviral therapy.","abstract_html":"Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the development of new therapeutic agents. However, little is known about the entry of FIPV. It is even questioned if the virus enters cells via direct fusion with the plasma membrane or after receptor-mediated internalization. In this thesis, the entry process of FIPV is studied to add upon the knowledge in FIPV pathogenesis and to evaluate the presence of possible targets for antiviral therapy.","abstract_has_math":false,"creators":["Van Hamme, Evelien"],"institution":"Ghent University. 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In this thesis, the entry process of FIPV is studied to add upon the knowledge in FIPV pathogenesis and to evaluate the presence of possible targets for antiviral therapy."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Entry of feline infectious peritonitis virus in blood monocytes"]}]}],"canonical_facts":{"dc:contributor":["Nauwynck, Hans","Dewerchin, Hannah"],"dc:creator":["Van Hamme, Evelien"],"dc:date":["2009"],"dc:description":["Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the development of new therapeutic agents. However, little is known about the entry of FIPV. It is even questioned if the virus enters cells via direct fusion with the plasma membrane or after receptor-mediated internalization. In this thesis, the entry process of FIPV is studied to add upon the knowledge in FIPV pathogenesis and to evaluate the presence of possible targets for antiviral therapy."],"dc:format":["application/pdf"],"dc:identifier":["https://biblio.ugent.be/publication/758320","http://hdl.handle.net/1854/LU-758320","urn:isbn:9789058641847","https://biblio.ugent.be/publication/758320/file/4335051"],"dc:language":["eng"],"dc:publisher":["Ghent University. 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