Tumor-assoziierte Mikroglia und Makrophagen modellieren durch GPNMB das Tumorwachstum und die Immunzellinfiltration in malignen Gliomen

Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Christian-Albrechts-Universität zu Kiel

Year

2026

Author dc:creator

• Yalcin, Fatih

Contributors dc:contributor

• Synowitz, Michael
• Baldus, Claudia

• CD44
• Experimental glioma
• GPNMB
• Glioblastoma
• Macrophage
• Microglia
• Mouse
• RCAS

Repository record source_url

https://macau.uni-kiel.de/receive/macau_mods_00008037

OAI identifier oai:identifier

oai:macau.uni-kiel.de:macau_mods_00008037