Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 450 for “"Glioblastoma"”.
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Nucleosome repositioning in glioblastoma
Glioblastoma multiforme (GBM) is the most malignant type of brain cancer in adults, with highly aggressive behaviour and low patient survival. The glial cells that are responsible for forming GBM show abnormalities in gene expression that can be caused by genetic or epigenetic causes. In …
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T Cell Exhaustion in Glioblastoma
<p>Glioblastoma (GBM) is the most common primary malignant brain tumor. Despite standard of care treatment GBM remains universally lethal, demonstrating a significant need for newer treatment strategies such as immunotherapy. Immune checkpoint blockade is a type of immunotherapy which seeks to …
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Cytokine secretion in glioblastoma patients
… rate approaching 80% in the first year of glioblastoma diagnosis. Their highly invasive nature renders local therapies such as surgery and radiation ineffective; whereas novel approaches such as immunotherapy are being actively studied as possible adjuncts in the treatment of patients with …
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Role of Ion Channels in Glioblastoma
Glioblastoma (GBM) accounts for the majority of astrocytic tumours and represents the most common primary brain cancer. Prognosis for patients is dismal even with aggressive treatment. Because of diffused GBM invasion throughout the brain, it is impossible for surgery to completely remove the …
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
Glioblastoma (GBM) is the most aggressive brain tumor that originates from glioblastoma stem cells (GSCs). In the brain, GSCs are supported by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high …
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MECHANOPROPERTIES, HETEROGENEITY AND CELL MIGRATION IN GLIOBLASTOMA
Glioblastomas (GBMs) are primary brain tumors endowed with inter- and intra-patient heterogeneity and extreme di↵usivity. As heterogeneity is studied with genomic and transcriptomic analysis, little is known on how it is reflected on cell migration, mechanoproperties and motility modes. Generally, …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
<p>Despite current multimodal therapies for glioblastoma (GBM) the prognosis remains very grim. There is a tremendous need to identify new genetic drivers which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific …
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… in the disease course and outcome. While glioblastoma multiforme (GBM) patients present uniform histological phenotypes, the molecular determinants of the disease vary considerably between individual cases resulting in complicated prognosis. The heterogeneity, aggressiveness and rapid …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
<p>Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent …
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The Overexpression of Basigin-3 in Glioblastoma
<p>Glioblastoma (GBM) is one of the most aggressive forms of brain tumor. With the current standard of care, survival prognosis for GBM patients is 15 months with a five-year survival rate of less than 3%. An increased understanding of the molecular mechanisms leading to cell growth and survival of …
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CHCHD2 and the tumor microenvironment in glioblastoma
Glioblastoma (GBM) is the most common, aggressive, and deadly form of primary brain tumor in adults, with a median survival time of only 14.6 months. GBM tumors present with chemo- and radio-resistance and rapid, diffuse invasion, making complete surgical resection impossible and resulting in …
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The Impact of Radiation on Glioblastoma Evolution
Glioblastoma (GB) is the most common and malignant primary adult brain cancer with a median survival of 15 months despite treatment with surgical resection followed by chemo-radiotherapy. The clonal diversity and evolutionary dynamics inherent to GBs is considered a major obstacle to effective …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
Glioblastoma (GB) is an inherently heterogenous and invasive primary brain tumour. Genetic and transcriptomic studies have attempted to classify GB into subtypes that can identify therapeutic vulnerabilities and predict survival, these include metabolic subtypes. An outstanding question and …
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Mechanism of acquired temozolomide resistance in glioblastoma
Glioblastoma (GBM) is the most common and malignant form of brain cancer. After aggressive treatment, therapy resistant tumors inevitably recur. However, the molecular mechanisms underlying such resistance remain unclear. We isolated GBM cells resistant to temozolomide (TMZ), the frontline …
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OPTIMIZED APPROACHES FOR LIQUID BIOPSY IN GLIOBLASTOMA PATIENTS
Background Glioblastoma (GBM) remains the deadliest primary brain tumour, with a 5-year survival < 4 % despite maximal multimodal therapy. Its diffuse infiltration, marked spatial-temporal heterogeneity, and the shielding effect of the blood–brain barrier (BBB) limit the accuracy of tissue biopsy …
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New advances in the chemotherapy of Glioblastoma multiforme
Glioblastoma multiforme is a primary tumor of the Central nervous System affecting mainly the brain. It is classified by the world health organisation as a grade IV glioma. It is indeed a very deadly tumor with an average life expectancy after diagnosis of about 14 months even after surgery, …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
Glioblastoma (GBM) is an aggressive brain cancer with a near-uniformly lethal prognosis. Anti-tumoural immunity remains low due to a highly suppressive tumour microenvironment. This project set out to identify immunomodulatory proteins secreted by glioblastoma, describe the distribution of …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
… AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of enzymatic cleavage by ADAM10/17. Here we used ELISA, BCA and BCG assays to characterize blood serum …
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