Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"CD44"”.
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Costimulatory function of CD44
… remained elusive. Here, I provide evidence that CD44 supports proliferation as well as apoptosis mainly, if not exclusively, by enhancing signal transduction via the TCR/CD3 complex. Blockade of CD44 interferes with mounting of an immune response. This has been demonstrated by the significantly …
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CD44 und variante Isoformen im murinen System
CD44, ein Molekül von großer Variabilität mit einer Vielfalt von Aufgaben. So augenfällig der Zusammenhang zwischen diesen beiden Tatsachen auch scheint, so wenig bestimmte er in den vergangenen Jahren die Forschung. Wichtige Arbeiten, die Funktionalität von CD44 betreffend, behandelten fast …
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The Role of CD44 in Concanavalin A-Induced Hepatitis
… the current study, we investigated the role of CD44 in Con A induced hepatitis. Although immune cells have been identified as the causative agent of Con A-induced hepatitis, the exact mechanism of pathogenesis remains unclear. When Con A was injected into CD44 wild type (WT) mice, it induced …
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Influence of Anti-CD44 on Murine B Cell Activation
… are indispensable to the immune system. CD44, an adhesion molecule, plays important roles in T cell activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known about its role in B cells. …
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Cd44-Mediated Collagen Remodeling Drives Wound Resolution And Pancreatic Tumorigenesis
… is vital to understanding disease progression. CD44 is a transmembrane cell-adhesion receptor that primarily binds to HA, the predominant glycosaminoglycan found in the ECM. Owing to it ubiquitous expression on nearly all neuroectodermal-derived cells, CD44 has been implicated in an array of …
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Role of CD44 in Immune Functions and Endothelial Cell Injury
… migration, homing and signal transduction. CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix. In the current study, we investigated whether HA or mAbs against CD44 would …
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Genomic Discovery of recurrent CD44-SLC1A2 Gene Fusion in Gastric Cancer
… cell line (SNU16) revealed expression of a CD44-SLC1A2 fusion transcript, caused by a paracentric chromosomal inversion, which was predicted to produce a truncated but functional SLC1A2 protein. In primary tumors, CD44-SLC1A2 gene fusions were detected in 1 to 2% of gastric cancers, but not …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… Proteoglycan 4 (PRG4) and its receptor CD44 and its transducer PP2A signaling axis play a biologically significant role in regulating urate crystal inflammation.</p> <p><br /><strong>Methods</strong>: Monocytes and macrophages were primed with TLR2 agonist and stimulated with MSU …
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Cd44-Hyaluronic Acid Interactions in Il-2 Induced Vascular Leak Syndrome
… studies from our laboratory demonstrated that CD44 knockout mice exhibit marked decrease in IL-2 induced VLS, thereby suggesting a role for CD44 in VLS. In the current study we tested whether use of mAbs against CD44 or hyaluronic acid (HA), the ligand for CD44, can abrogate IL-2 induced VLS. …
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Regulation and function of hyaluronan binding by CD44 in the immune system
The proteoglycan CD44 is a widely expressed cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and is involved in processes ranging from metastasis to wound healing. In the immune system, leukocyte activation induces hyaluronan binding through changes in CD44 …
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Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
… with treatment resistant metastatic disease. The CD44 cell adhesion molecule and the Ezrin cytoskeletal adaptor protein have emerged as potential drivers of metastasis and drug resistance in cancers of the breast and other organs. Their known ability to physically interact, and their overlapping …
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Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process
The cell-cell and cell-matrix adhesion molecule CD44 and its numerous splice variants are involved in a multitude of physiological and pathological processes, including tumour progression. Especially variant CD44 has been implicated in metastasis formation. For long term in vivo experiments on …
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Elucidating The Role of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment
… This study was designed to assess the role of CD44 in the migration of MSC toward the tumor microenvironment and to determine the implications of CD44-deficient MSC within the tumor stroma. Inhibition of MSC migration was evaluated through a variety of methods in vitro and in vivo including …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
… leads to an inflammatory response. The CD44 receptor is highly expressed in macrophages and plays an essential role in inflammation. The binding of endogenous ligands to CD44 on the surface of macrophages was shown to result in ligand internalization. In this project, we aimed to assess …
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Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells
… recently. It has also been shown that CD44, an adhesion molecule, can participate in signaling cytotoxic activity of cytotoxic T lymphocytes (CTLs). In the current study we tested the hypothesis that activation of natural killer (NK) or lymphokine activated killer (LAK) cells induces …
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Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2
… of the exogenous over-expression of two 3’UTRs, CD44 and Tumour Suppressor candidate 2 (TUSC2), on miRNA functions in breast cancer carcinogenesis were investigated. A series of cell function assays in human and mouse breast cancer cell lines, MT-1, MDA-MB-231 and 4T1 showed phenotypic changes …
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IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
… through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A synthetic IGFBP-3 peptide (<sup>215</sup>-KKGFYKKKQCRPSKGRKR-<sup>232</sup>) but not …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… that cluster of differentiation (CD) 74 and CD44 act in synergy and are susceptible to the effect of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like inflammatory mediator, whose ligand is the transmembrane receptor CD74. Recent data suggests that CD74 is …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
… one of the most common cancers in the world. CD44 is a biomarker that is overexpressed in most types of cancer cells, including breast cancer. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate A (CSA), are known as binding ligands of CD44 receptor and were used as …
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