Innovatives liposomes for overcoming biological barriers

In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests.

Grantor dc:publisher

Università degli Studi di Cagliari

Year dc:date

2013

Author dc:creator

• CHESSA, MAURA

• Liposomi promotori dell'assorbimento
• curcumin
• curcumina
• ficocianina
• liposomes penetration enhancer
• phycocyanin
• quercetin
• quercetina
• Settore CHIM/09 - Farmaceutico Tecnologico Applicativo

Statement dc:rights

• info:eu-repo/semantics/openAccess
• license:Non specificato

Language dc:language

eng

Handle dc:identifier

http://hdl.handle.net/11584/266227

OAI identifier oai:identifier

oai:iris.unica.it:11584/266227