{"id":{"repo_id":"cagliari","oai_identifier":"oai:iris.unica.it:11584/266227"},"canonical_url":"https://search.dev.ndltd.org/etd/cagliari/oai:iris.unica.it:11584/266227","repository":{"repo_id":"cagliari","name":"Università di Cagliari","base_url":"https://iris.unica.it/oai/request"},"display":{"title":"Innovatives liposomes for overcoming biological barriers","abstract":"In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests.","abstract_html":"In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. 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Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes loading quercetin and phycocyanin are designed for a topical application and were tested on new born pig skin. Liposomes and chitosomes loading curcumin are designed for pulmonary delivery as a cure for cystic fibrosis. In this case, has been tested the toxicity of the system using a model of lung tissue using Calu-3 cells. The drug delivery via liposomes and chitosomes improves the retention time of the drug and increases its stability. Studies continue with biocompatibility and in vivo tests."]},{"key":"dc:title","label":"Title","values":["Innovatives liposomes for overcoming biological barriers"]}]}],"canonical_facts":{"dc:creator":["CHESSA, MAURA"],"dc:date":["2013-04-11"],"dc:description":["In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. 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Studies continue with biocompatibility and in vivo tests."],"dc:identifier":["http://hdl.handle.net/11584/266227"],"dc:language":["eng"],"dc:publisher":["Università degli Studi di Cagliari"],"dc:relation":["numberofpages:91"],"dc:rights":["info:eu-repo/semantics/openAccess","license:Non specificato"],"dc:subject":["Liposomi promotori dell'assorbimento","curcumin","curcumina","ficocianina","liposomes penetration enhancer","phycocyanin","quercetin","quercetina","Settore CHIM/09 - Farmaceutico Tecnologico Applicativo"],"dc:title":["Innovatives liposomes for overcoming biological barriers"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-24T01:30:03Z"}