Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"curcumin"”.
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Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
Curcumin is a naturally available polyphenolic compound that has demonstrated chemotherapeutic effects in several carcinogenic models as well as pre-clinical trials. However, its poor oral bioavailability due to extremely low aqueous solubility, poor permeability and extensive pre-systemic …
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Cancer Chemoprevention by Curcumin and Structurally Related Beta-Diketones
Curcumin is a beta-diketone constituent of the spice turmeric that possesses anticarcinogenic properties in several animal models. However, the effectiveness of curcumin to act as an inhibitor of mammary carcinogenesis needs further attention. The present studies were conducted in order to evaluate …
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Metabolomic profiling to investigate effect of curcumin in lung cancer
<p>Lung cancer is the leading cause of cancer deaths in the US, in part due to poor diagnosis. Prognosis can be improved, if detected at an early stage. The objective of this study was to use the metabolomic approach to investigate early potential biomarkers for lung cancer. Golden Syrian hamsters …
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Can curcumin improve the methotrexate based treatment for rheumatoid arthritis?
… adverse effects. One such promising option is curcumin, an active compound extracted from Indian spice Turmeric. Various studies have indicated the synergistic properties exhibited by curcumin and its ability to modulate the underlying inflammatory pathways involved in RA. However, no previous …
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Synergistically active curcumin resveratrol solid lipid nanoparticles for treatment of melanoma
Poorly soluble polyphenols such as curcumin and resveratrol have shown significant potential in the treatment of melanoma due to their multifarious roles in its pathogenesis. Furthermore, the combination of curcumin and resveratrol was found to demonstrate synergistic effects in other cancers; …
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Novel insights into the interaction between iron and curcumin and its physiological consequences
… events. Co-administration of ferrous iron with curcumin, a polyphenol from turmeric root, might ameliorate oral iron- and exercise-induced GI disturbances due to its potent antioxidant and anti-inflammatory activity. Therefore, this thesis aimed to explore the co-administration of supplemental …
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The Effects of Curcumin On Body Composition of Patients With Advanced Pancreatic Cancer
… depletion) is associated with worse outcomes. Curcumin has shown a myriad of biological effects, including anti-cancer and anti-inflammatory. The ability of curcumin to attenuate cachexia and muscle loss has been tested in animal models, with conflicting results so far. The hypothesis of this …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
… are centered on the anti-cancer properties of curcumin, a turmeric derivative, on these intracellular and intercellular resistance mechanisms. The long term goal of this research is to determine the mechanisms by which curcumin modulates intracellular pathways related to pancreatic cancer …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
Curcumin is the active ingredient present in the roots and rhizomes of the tropical plant known as Curcuma Longa (Turmeric). Scientific research has identified curcumin to possess various pharmacological properties including, anti-inflammatory and anticancer activities. This novel research focused …
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Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters
… transport between the epithelial cells. BH-curcumin was also found in the lymph vessels of one of the animal that received BH-visual probe suspension and was sacrificed 15 min after inhalation. There was no visual probe detected in any organ 30 min after inhalation of any formulations.
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Spectroscopic investigations on the molecular motions and solution chemistry of the medicinal pigment curcumin.
Curcumin is the bioactive molecule in the pigments found in turmeric, a spice and traditional medicine in Asia for centuries. Research has shown that curcumin exhibits a number of medicinal benefits, in particular, anti-Alzheimer’s and anti-cancer properties. It has been shown that there is an …
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The antiplasmodial, toxicity and pharmacokinetic properties of synthetic derivatives of the natural product Curcumin
Includes bibliographical references.
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In Vitro Effects of Actively Delivered Coencapsulated Curcumin and Cisplatin Nanoliposomes on Squamous Oral Carcinoma
Multidrug carriers were also formulated using a Dipalmitoyl Phosphatidylcholine (DPPC) as a primary lipid, with incorporation of a lysolipid to achieve controlled release of the drugs loaded within. Diagnostic ultrasound energy was then employed as a tool to achieve controlled release from the …
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The Effect of Curcumin on Oxidative Stress and Inflammatory Markers in Recreationally Active Women and Men
… elevations of oxidative stress and inflammation. Curcumin, a bioactive compound found in turmeric, has been linked to antioxidant and anti-inflammatory properties. While cell line and animal studies have demonstrated the antioxidant and anti-inflammatory potential of curcumin, its effects in …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… studies demonstrated that two phytochemicals, Curcumin (Curc) and ursolic acid (UA), exert synergistic effects on tumor growth in a xenograft model of PCa. In the current studies, we demonstrated that Curc+UA administered through the diet significantly inhibited prostate tumor progression in …
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Development of New Synthetic Methods for Transition Metal-Catalyzed Organic Reactions and Synthesis of Curcumin-Based Adducts
… two antitumor molecules, methotrexate and curcumin. The initial attempt to directly connect these two molecules via an ester bond proved unsuccessful due to their chemical incompatibility, leading to decomposition of the adduct during synthesis. To address this challenge, a dodecanoic …
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Curcumin-related hybrid compounds as potential antimalarial agents : design, synthesis, mechanistic investigations, biological evaluation and pharmacokinetic studies
… are structurally related to the natural product curcumin, and which exhibit in vitro and in vivo antimalarial activity. Part of the study involved investigations into the pharmacokinetics and possible antimalarial mechanisms of action of selected target compounds.
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The Influence of Quercetin, Curcumin, and Resistance Exercise On Anabolic Signaling In the Skeletal Muscle of Cachectic Mice
… naturally found nutraceuticals, quercetin and curcumin, as well as resistance exercise have all been shown to indirectly or directly influence molecular factors involved in increasing net protein synthesis. Thus the purpose of this study was to examine if quercetin or curcumin supplementation, …
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