Mechanismen der Restenosierung nach koronarer Stentimplantation : ein Paargruppenvergleich zwischen Diabetikern und Nicht-Diabetikern

Diabetes mellitus is an established risk factor for stent restenosis, in part as a result of smaller vessel dimensions and longer lesions. Aim of this study was to compare the magnitude of acute lumen gain and late lumen loss after elective coronary stent implantation in diabetic and non-diabetic patients using a matched-pair analysis. A total of 133 diabetic patients with 192 coronary lesions were included into this analysis. From a database of 993 non-diabetic patients, a group of 192 lesions in 182 non-diabetic patients were matched in a pairwise fashion stratifying for reference diameter (RD), minimal lumen diameter (MLD) and lesion length (LL). All patients underwent a follow-up angiography (FUA) 5±2 month post intervention. Preinterventional baseline angiographic matching variables as well as mean stent length, stent diameter, and maximal implantation pressure were not different. The binary restenosis rate at 5 month FUA was 25% in the diabetes group and 14% in the non-diabetes group (p<0.01). Both, acute angiographic lumen gain (1.47±0.41 vs. 1.56±0.38mm, p=0.03), as well as late lumen loss (0.64±0.42 vs. 0.55±0.36mm, p=0.02) were significantly different between diabetic and non-diabetic patients. Suboptimal acute procedural results and the exaggerated neointimal proliferation contributed by about 50% to the lower net lumen gain in diabetic patients. Patients with diabetes mellitus show a significantly higher restenosis rate even if matched for preprocedural angiographic lesion dimensions. Mechanistically, inferior procedural results as well as exaggerated neointimal proliferation are quantitatively equally important for this process.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2007

Author dc:creator

• Friese, Klara Maria

Contributors dc:contributor

• Radke, Peter Walter

• info:eu-repo/classification/ddc/610
• Diabetes
• Stent
• Restenose
• Medizin
• restenosis

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114336%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A52094