Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"restenosis"”.
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Restenosis of Coronary Artery Disease on the Implementation of Family Support and Health Behavior Research
… health behavior compliance for coronary artery restenosis patients helping prevent re-stenosis and promote health behavior. Subjects of the study were 80 patients were enrolled who got medical or surgical re-intervention after PCI for coronary artery re-stenosis at a general hospital at …
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Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants
… disease progression while awaiting PTA Moreover restenosis following PTA is a major therapeutic problem despite high initial success rate, limiting the long-term efficacy of the procedure. There is growing evidence that the tissue factor-tissue factor pathway inhibitor (TF-TFPI) interaction, a …
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Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty
… major cause of CVD-related death and disability. Restenosis is common, occurring in 40-60% of cases at 12 months following lower extremity percutaneous transluminal angioplasty (PTA). No such method exists to identify patients who are at risk from restenosis before intervention. Tracers of …
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The role of altered cyclic strain patterns on proliferation and apoptosis of vascular smooth muscle cells - implications for in-stent restenosis
… main drawback of stent implantation is in-stent restenosis. Restenosis is a partial re-occlusion of the arterial wall predominantly due to vascular smooth muscle cells (SMC) migration from the media to the intima and subsequent SMC proliferation. A stent procedure dramatically alters the level of …
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Haematopoietic progenitor cells in carotid disease
… significant carotid disease or correlate with restenosis following carotid endarterectomy (CEA). Methods Initially the assay conditions to measure HPC number and function were optimized. HPC numbers were measured by flow cytometry (CD133+ve/CD34+ve) and early colony forming unit assay (eCFU). …
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Inhibition of Vascular Smooth Muscle Cell Migration and Intimal Thickening with Chimeric N-Cadherin Mimetic Peptides: Development of a Novel Therapeutic Strategy for Restenosis
… and stenting, which has side effects of restenosis (re-narrowing) from smooth muscle cell (SMC) migration and proliferation, and late thrombosis due to endothelial cell (EC) death from indiscriminately cytotoxic chemotherapeutic agents. We developed a chimeric peptide with a mimetic …
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RHAMM Alters Vascular Smooth Muscle Cell Constrictive Matrix Remodeling
Restenosis, which is defined as a new lumen narrowing at the site of previous vascular reconstruction, affects millions of patients each year worldwide. Restenosis has been a major limitation of surgical and endovascular reconstructions since their inception and while decades of research have …
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Hemocompatible polymer thin films fabricated by Electrostatic Self-Assembly (ESA)
… the arteries. The major complication of stent is restenosis. Current development of drug-eluting stents shows successfully reduce the occurrence of restenosis. Other than using drugs, electrostatic self assembled (ESAd) thin films may be the potential candidates to prevent restenosis. ESA is a …
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Experimentelle Untersuchungen am porzinen „over-sized coronary stent“-
… over-sized coronary stent-model for in-stent-restenosis rate after implantation of uncoated niob-zirkonium stents and niob-zirkonium stents coated with iridiumoxide. Background: The treatment of atherosclerotic stenosis in coronary artery disease with balloon expandable coronary stents has …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… due to poor patency outcomes with high rates of restenosis secondary to a phenomenon called Intimal Hyperplasia (IH). We have performed previous animal studies using 2mm TEVG in rabbits and 5mm TEVG in sheep which had restenosis rates secondary to IH of 70% and 60% respectively. IH is secondary …
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Characterization of Everolimus In Biodegradable PLAF/PLEOF Nanoparticle
… stents (DES) have prolonged the progression of restenosis in coronary arteries, however, their use in larger vessels remain suboptimal. The drugs elude off within the first week, and a delayed release may retard development of restenosis in larger vessels. Therefore, biodegradable core-shell …
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Reoxygenation of hypoxic coronary smooth muscle cells amplifies growth-retarding effects of ionizing irradiation
… potential targets for brachytherapy to prevent restenosis after percutaneous transluminal angioplasty. It is unclear whether gene expression, apoptosis rate and production of reactive oxygen species of these cells undergoing alpha-irradiation are changed by reoxygenation. <br>Hypoxic and …
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Market application of a novel stent-based patency monitor to the management of ischemic vascular disease
… deterioration. A phenomenon called stent restenosis post procedure exists which puts patients at a relatively high risk for vessel stenosis and occlusion. Stent restenosis may eventually lead to clinical symptoms such as myocardial infarction, stroke or limb loss, and if overlooked might …
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Resistance to Apoptosis in Smooth Muscle Cells and Stent-Induced Stenosis in Coronary and Peripheral Arteries
… cases, success is limited by re-narrowing (restenosis) of the artery. Stenting offers the advantage of a slightly lower restenosis rate. However, this rate is still significant. Studies aimed at further understanding the restenotic disease process and the cells that contribute to it would …
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Seeding of Titanium Surfaces and Nitinol Stents with Blood-Derived Endothelial Cells
… may reduce the incidence of clotting and restenosis complications and also reduce the need for risky anticoagulation therapy following implantation of such devices. We developed a novel cell therapy for seeding autologous endothelium onto blood-contacting vascular stents at the point of …
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Clinical outcome and Predictive factors of Coronary aneurysm after Percutaneous Coronary Intervention
… poor clinical outcomes including in-stent restenosis and stent thrombosis after drug-eluting stent (DES) implantation were increased with CAAs after DES implantation (James et al., 2009). In this study to assess the clinical outcome of CAAs and PSS after percutaneous coronary intervention …
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Modeling and simulation of coronary stents: Intravascular drug delivery and arterial drug distribution
In-stent restenosis still occurs in coronary arteries implanted with drug-eluting stents, with the maximum thickness observed at the vascular site of maximum inter-strut angle. This phenomenon may be related to the specific spatiotemporal drug uptake in the arterial wall. In this work local …
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Mechanical properties of arterial wall
The incidence of restenosis has been shown to be correlated with the overstretching of the arterial wall during an angioplasty procedure. It has been proposed that slow balloon inflation results in lower intramural stresses, therefore minimizing vascular injury and restenosis rate. The analysis of …
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Novel strategies for optimising drug release from medicinal implants
In-stent restenosis (ISR) is a significant limitation of percutaneous coronary revascularisation procedures, occurring in around 30% of patients. Implantation of the sent produces an intense inflammatory response. This leads to high levels of smooth muscle cell (SMC) proliferation and migration, …
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