Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz

Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the aspirin-intolerance. In this study the leukotriene receptors CysLTR 1 and CysLTR 2 were analyzed to genetic variants. A single nucleotide exchange from thymine to cytosine at position 927 (927 T -> C) was found in the coding region for receptor 1 (C-terminus). The next step was to analyze DNA of 133 cases and 270 age-and gender-matched controls for the presence of this polymorphism. This analysis shows the frequency of the polymorphism is statistically significant higher in the cases. (OR 2,04, CI: 1,271-3,282). Furthermore it was found that TC- and CC-carriers among females (the gene for CysLTR 1 is located on X chromosome (Xq13-q21)) are statistically significantly increased (OR 1,89, CI: 1,09-3,277).

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2008

Author dc:creator

• Scheja, Annette Katharina

Contributors dc:contributor

• Blömeke, Brunhilde

• info:eu-repo/classification/ddc/610
• Leukotriene
• Acetylsalicylsäure
• Intoleranz
• Rezeptor
• Polymorphismus
• Medizin
• Leukotrienrezeptoren
• CysLTR1
• CysLTR2
• Aspirin-Intoleranz
• leukotriene receptors
• aspirin intolerance

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50430