{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:50430"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:50430","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz","abstract":"Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the aspirin-intolerance. In this study the leukotriene receptors CysLTR 1 and CysLTR 2 were analyzed to genetic variants. A single nucleotide exchange from thymine to cytosine at position 927 (927 T -> C) was found in the coding region for receptor 1 (C-terminus). The next step was to analyze DNA of 133 cases and 270 age-and gender-matched controls for the presence of this polymorphism. This analysis shows the frequency of the polymorphism is statistically significant higher in the cases. (OR 2,04, CI: 1,271-3,282). Furthermore it was found that TC- and CC-carriers among females (the gene for CysLTR 1 is located on X chromosome (Xq13-q21)) are statistically significantly increased (OR 1,89, CI: 1,09-3,277).","abstract_html":"Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the aspirin-intolerance. In this study the leukotriene receptors CysLTR 1 and CysLTR 2 were analyzed to genetic variants. A single nucleotide exchange from thymine to cytosine at position 927 (927 T -> C) was found in the coding region for receptor 1 (C-terminus). The next step was to analyze DNA of 133 cases and 270 age-and gender-matched controls for the presence of this polymorphism. This analysis shows the frequency of the polymorphism is statistically significant higher in the cases. (OR 2,04, CI: 1,271-3,282). Furthermore it was found that TC- and CC-carriers among females (the gene for CysLTR 1 is located on X chromosome (Xq13-q21)) are statistically significantly increased (OR 1,89, CI: 1,09-3,277).","abstract_has_math":false,"creators":["Scheja, Annette Katharina"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Blömeke, Brunhilde"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-30T19:40:25Z","subjects":["info:eu-repo/classification/ddc/610","Leukotriene","Acetylsalicylsäure","Intoleranz","Rezeptor","Polymorphismus","Medizin","Leukotrienrezeptoren","CysLTR1","CysLTR2","Aspirin-Intoleranz","leukotriene receptors","aspirin intolerance"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/50430","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50430","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Blömeke, Brunhilde"]},{"key":"dc:creator","label":"Author","values":["Scheja, Annette Katharina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-25702"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Leukotriene","Acetylsalicylsäure","Intoleranz","Rezeptor","Polymorphismus","Medizin","Leukotrienrezeptoren","CysLTR1","CysLTR2","Aspirin-Intoleranz","leukotriene receptors","aspirin intolerance"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/50430","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the aspirin-intolerance. In this study the leukotriene receptors CysLTR 1 and CysLTR 2 were analyzed to genetic variants. A single nucleotide exchange from thymine to cytosine at position 927 (927 T -> C) was found in the coding region for receptor 1 (C-terminus). The next step was to analyze DNA of 133 cases and 270 age-and gender-matched controls for the presence of this polymorphism. This analysis shows the frequency of the polymorphism is statistically significant higher in the cases. (OR 2,04, CI: 1,271-3,282). Furthermore it was found that TC- and CC-carriers among females (the gene for CysLTR 1 is located on X chromosome (Xq13-q21)) are statistically significantly increased (OR 1,89, CI: 1,09-3,277)."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University III, 68 S. : graph. Darst. (2008). = Aachen, Techn. Hochsch., Diss., 2008"]},{"key":"dc:title","label":"Title","values":["Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz"]}]}],"canonical_facts":{"dc:contributor":["Blömeke, Brunhilde"],"dc:coverage":["DE"],"dc:creator":["Scheja, Annette Katharina"],"dc:date":["2008"],"dc:description":["Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. Important is that a cross reaction to other nonsteroidal anti-inflammatory drugs (NSAID) is possible. The pathogenesis is not sufficient cleared. Aspirin’s target is to inhibit the cyclooxygenase. This leads to a decrease in the level of prostaglandin biosynthesis. The arachidonic acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the aspirin-intolerance. In this study the leukotriene receptors CysLTR 1 and CysLTR 2 were analyzed to genetic variants. A single nucleotide exchange from thymine to cytosine at position 927 (927 T -> C) was found in the coding region for receptor 1 (C-terminus). The next step was to analyze DNA of 133 cases and 270 age-and gender-matched controls for the presence of this polymorphism. This analysis shows the frequency of the polymorphism is statistically significant higher in the cases. (OR 2,04, CI: 1,271-3,282). Furthermore it was found that TC- and CC-carriers among females (the gene for CysLTR 1 is located on X chromosome (Xq13-q21)) are statistically significantly increased (OR 1,89, CI: 1,09-3,277)."],"dc:identifier":["https://publications.rwth-aachen.de/record/50430","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112976%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-25702"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University III, 68 S. : graph. Darst. (2008). = Aachen, Techn. Hochsch., Diss., 2008"],"dc:subject":["info:eu-repo/classification/ddc/610","Leukotriene","Acetylsalicylsäure","Intoleranz","Rezeptor","Polymorphismus","Medizin","Leukotrienrezeptoren","CysLTR1","CysLTR2","Aspirin-Intoleranz","leukotriene receptors","aspirin intolerance"],"dc:title":["Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:40:25Z"}