Global ETD Search
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Showing 1 to 9 of 9 for “"CysLTR1"”.
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Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz
Acetylsalicylic acid (Aspirin) is one of the most frequently used drugs in the world. The importance of aspirin is not only the role as an analgesic, it is also used in the prophylaxis of ischemic heart desease and strokes. The aspirin-intolerance occurs in 0,3-0,9% of the general population. …
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Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4
… in eosinophilic airway inflammation of AIA via CysLTR1-mediated mechanism. Leukotriene modifier MK-571, a selective CysLTR1 antagonist, is widely used in the management of asthma. We selected Cysteinyl leukotruene receptor 1 (CysLTR1) among leukotriene ？ related genes and screened for genetic …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… through three G-protein coupled receptors (CysLTR1, CysLTR2 and GPR99). The CysLTR1 and its ligands function has been well elucidated in asthmatic and allergic responses however, its role in bacterial infections is unknown. The aim of our study was to elucidate the role of CysLTR1 on disease …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… through cysteinyl leukotriene receptor-1 (cysLTR1) and have been reported to drive Th2 immune responses. Initiation and amplification of robust Th2 immune responses is crucial for conferring protective immunity to helminth (Schistosoma mansoni and Nippostrongylus brasiliensis) infection in …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… interact with three G-protein-coupled receptors (CysLTR1, CysLTR2, and GPR99). While the role of CysLTR1 and its ligand has been studied in asthmatic and allergic responses, its function during bacterial infections remains unclear. Our study aims to elucidate the role of CysLTR1 in disease …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… receptor, cysteinyl leukotriene receptor 1(CysLTR1). CCL2 (MCP-1, Monocyte Chemoattractant protein-1) is one of the major chemokines responsible for attracting monocytes. CXCL10 (IP-10, IFN-γ-inducible protein 10kDa) is an IFN-γ-inducible chemokine that preferentially attracts activated Th1 …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… its receptors, cysteinyl leukotriene receptor 1 (CysLTR1), for its role in resistance or susceptibility to L. major-induced CL. In male and female BALB/c mice homozygous deficient for CysLTR1, we found that disease progression, parasite burdens, antibody and cytokine responses showed no …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… cells suggested a highly selective expression of CYSLTR1 by human Th2 cells. Subsequent RT-PCR analysis confirmed that Th2 cells selectively express CYSLTR1 mRNA at high levels. Calcium signalling experiments revealed that Th2 cells respond selectively to leukotrienes compared to Thl cells, with a …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… ADCY9 132007 T>C (Ile772Met), ALOX5 -1708 G>A, CysLTR1 -634 C>T, CysLTR2 2079 C>T, 2534 A>G, IL10 -1082 A>G, IL13 -1510 A>C, LTC4S -1072 G>A, LTC4S -444 A>C, NK2R 7853 G>A (Gly231Glu), TNFα -1031 T>C and TNFα -308 G>A were analyzed. First, we tested the therapeutic response to combination …