Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CysLTR2"”.
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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
… oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein-coupled receptor (GPCR) cysteinylleukotriene receptor 2. The mutant CYSLTR2 encodes for CysLTR2-L129Q receptor, with the substitution of Leu to Gln at position 129 (3.43). The ability of CysLTR2-L129Q to …
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Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras
… relevant GPCR, cysteinyl leukotriene receptor 2 (CysLTR2), which is associated with uveal melanoma (UM). UM is an eye cancer that develops in melanocytes with high mortality rates due to high incidence of metastasis. In a subset of cases, the oncogenic driver is the activating mutation in the gene …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… with three G-protein-coupled receptors (CysLTR1, CysLTR2, and GPR99). While the role of CysLTR1 and its ligand has been studied in asthmatic and allergic responses, its function during bacterial infections remains unclear. Our study aims to elucidate the role of CysLTR1 in disease progression …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… three G-protein coupled receptors (CysLTR1, CysLTR2 and GPR99). The CysLTR1 and its ligands function has been well elucidated in asthmatic and allergic responses however, its role in bacterial infections is unknown. The aim of our study was to elucidate the role of CysLTR1 on disease …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… CysLTR1 expression. Importantly, expression of CysLTR2 did not appear to compensate for lack of CysLTR1 in CysLTR1-/- mice. Overall, these findings indicate that CysLTR1, as a host factor, is dispensable to the non- healing response associated with CL caused by L. major in mice.
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… (Ile772Met), ALOX5 -1708 G>A, CysLTR1 -634 C>T, CysLTR2 2079 C>T, 2534 A>G, IL10 -1082 A>G, IL13 -1510 A>C, LTC4S -1072 G>A, LTC4S -444 A>C, NK2R 7853 G>A (Gly231Glu), TNFα -1031 T>C and TNFα -308 G>A were analyzed. First, we tested the therapeutic response to combination inhaler according to …