Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 276 for “"TH2"”.
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… a role for IFN-α/β in the regulation of Th2 development as well as memory Th2 cell function. The Th2 master transcription factor GATA3, promotes its own expression through a positive regulatory loop, uncoupling the cell from the requirement of IL-4 signaling. IFN-α/β inhibits this process …
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Granzym B und TH1/TH2-Zytokine bei Asthma Bronchiale und Rheumatoider Arthritis
… B, der Th1-Zytokine (IL-2, IFN-g, TNF-a) und Th2-Zytokine (IL-4, IL-5, IL-10) untersucht. Das Probenmaterial bestand aus bronchoalveolärer Lavage (BAL) von Probanden mit Asthma bronchiale 10 Minuten und 42 Stunden nach segmentaler Allergenprovokation (SAP) und aus Synovialflüssigkeiten von …
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The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis
… still have progressive active TB. Whether a Th2-like immune response (IL-4; IL-4δ2; IL-9) can subvert protective host immunity requires clarification.
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Die massive Expression von NF-ATc/A ist eine Eigenschaft Antigen-erfahrener Th1- und Th2-Zellen und trägt zur selektiven Induktion des IL-4 Promotors in Th2-Zellen bei
… der Induktion des IL-4 Promotors sowie bei der Th2-Zelldifferenzierung. Mit Hilfe eines murinen in vitro T-Zelldifferenzierungsmodells konnten wir zeigen, dass nur die Expression der kurzen Isoform NF-ATc/A induziert wird, während die der längeren Isoformen NF-ATc/B und NF-ATc/C nahezu …
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Modelos Th1 y Th2 de secreción in vitro de citoquinas en pacientes polínicos
… que las células con fenotipo de secreción Th2 (productoras de IL-4 e IL-5 pero no –o en cantidades limitadas- de IFN-γ), se acumulan en la sangre circulante y/o en los órganos diana de lso pacientes que sufren parasitación por helmintos o procesos atópicos. Dicha subpoblación de células, de …
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Einfluss von Interleukin-18 auf das Th1/Th2-Zytokingleichgewicht mononukleärer Nabelschnurblutzellen in vitro
… Jahren konnte für IL-18 zudem die Induktion Th2-spezifischer Zytokine aufgezeigt werden. Bei Atopikern, welche durch das Überwiegen der Th2- gegenüber der Th1-Immunantwort gekennzeichnet sind, ist gegenüber der nichtatopischen Kontrollgruppe eine signifikant höhere plasmale …
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
The evaluation of vaccines for human use requires reliable models of infection, that are predictive of protective efficacy. Traditionally whole cell pertussis vaccines (Pw) have been controlled using the Kendrick test, which measures protection following intracerebral challenge with Bordetella …
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Methode zur Charakterisierung des Arginin-Metabolismus einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
… einzelner Makrophagen nach Stimulation mit Th1 & Th2 Zytokinen
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events evident in this disease stem from a failure to regulate the underlying immune response. How these events …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events evident in this disease stem from a failure to regulate the underlying immune response. How these events …
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The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer
… host immune response against the tumour. The Th1/Th2 cytokine profile plays an important part in determining how the immune system operates and modulation of this has potential therapeutic value.The efficacy of treatment for colorectal cancer is based on four primary end points: tumour response …
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Prolonged T – DC macro-clustering within lymph node microenvironments initiates Th2 differentiation in a site-specific manner
T helper 2 (Th2) responses protect against pathogens while also driving allergic inflammation, yet how large-scale Th2 responses are generated in tissue context remains unclear. Here, we used quantitative imaging to investigate early Th2 differentiation within lymph nodes (LNs) following cutaneous …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
CD23 has long been appreciated to be a natural, negative regulator of IgE synthesis. This understanding is due in part to animal models in which CD23 deficient or CD23 transgenic animals display exacerbated or reduced IgE levels respectively. Interestingly, CD23 is susceptible to proteolytic …
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Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… Da Vorarbeiten nahe legten, dass das Th2-Zytokin IL-10 und das Th1-Zytokin IL-12 dichotom in Monozyten exprimiert werden, wurden insbesondere die Antigen-präsentierenden Eigenschaften der unterschiedlichen Monozytengruppen untersucht. <br>Wir konnten zeigen, dass sich insbesondere die …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
The role of Th1 (IL,-2 and IFN-gamma) and Th2 (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
Antigen-specific Th2 cells are central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… mediate cell-mediated immunity, T-helper-2 (Th2) which orchestrates humoral immunity and T-helper-17 (Th17) cells key players in autoimmunity response. Cytokine induced transcription factors that are differentially expressed in Th cells are required for the development and commitment to a …
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Protein Kinase A regulates GATA-3 dependent Activation of IL-5 Gene Expression in T Helper Lymphocytes
… Zytokine und stimuliert die Synthese Th2-typischer Zytokine. Die für die cAMP-vermittelte Induktion von Th2-Zytokinen verantwortlichen Signaltransduktionskaskaden sind bisher nur unvollständig aufgeklärt. Deshalb konzentrierte sich meine Dissertation auf die Erforschung des …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… helper (Tfh) lineage while repressing Th1, Th2 and Th17 differentiation. Bcl6-deficient mice develop a spontaneous and severe Th2-type inflammatory disease including myocarditis and pulmonary vasculitis, suggesting a potential role for Bcl6 in Treg cell function. Bcl6-deficient Treg cells …
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