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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 197 for “"Cyclodextrin"”.
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Cyclodextrin complexes of antimicrobial agents
… an increase in solubility in the presence of cyclodextrins (CyD) due to the formation of a water-soluble complex between the drug and dissolved CyD. This study investigated the interactions of -Cyd and hydroxypropyl--CyD (HP--CyD, M.S. = 0.6) with antimicrobial agents of limited solubility in …
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Physicochemical characterisation of cyclodextrin-drug complexes
The cyclodextrins and their derivatives are finding increasing application in the pharmaceutical industry as carrier molecules for many drugs, as complexation can result in improved physical characteristics such as increased aqueous solubility and dissolution rates. The aim of this work was to …
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Cyclodextrin-based rotaxanes for material science applications
In the work described in this thesis, CD-based rotaxanes were prepared and their solid-state structures/packing, morphology and crystal growth behaviour were explored. Encapsulation of profluorescent nitroxides through rotaxane formation demonstrated the use of CD-based rotaxanes to change the …
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Cyclodextrin-based rotaxanes for material science applications
In the work described in this thesis, CD-based rotaxanes were prepared and their solid-state structures/packing, morphology and crystal growth behaviour were explored. Encapsulation of profluorescent nitroxides through rotaxane formation demonstrated the use of CD-based rotaxanes to change the …
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The Effect of Cyclodextrin on Reductive Dechlorination
… was to determine if and how the addition of cyclodextrin (CD) affects reductive dechlorination of chlorinated ethenes. After chlorinated solvent degradation rates were established in anaerobic and aerobic microcosms, 100 mg/L of CD solution was added for a period of 21 days. CD was then …
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Synthesis and Properties of Selectively Modifiable Cyclodextrin Analogues
Cyclodextrins (CDs) are amphiphilic carbohydrate based macrocycles that have been under-utilized in supramolecular chemistry due to difficulties surrounding the selective functionalization of the hydroxyl groups on the macrocycle. A novel strategy for the synthesis of CD analogues is described …
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ß-Cyclodextrin-haltige Filmüberzüge zur Dickdarm-spezifischen Wirkstoff-Freisetzung
… sind für derartige Coatings geeignet. b-Cyclodextrin (b-CD) ist ein solches Oligosaccharid. Gegenstand dieser Arbeit war es, einen Überzug für feste Arzneiformen zu finden, der b-CD als bioabbaubaren Hilfsstoff enthält. <br>Der Abbau von gelöstem b-CD durch a-Amylasen unterschiedlichen …
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Formation, Characterization and Stability of Natural Antimicrobial-Cyclodextrin Complexes
… and citronellol were complexed with α- and β-cyclodextrin and evaluated through phase solubility analyses. The complexes formed showed improved aqueous solubility for all compounds. Complexation with α-CD resulted in an increase of aqueous solubility of o-methoxycinnamaldehyde by 10-fold, …
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Targeted Degradation of Trinitrotoluene Using Iron (II)-Cyclodextrin-Peroxide Systems
… plants generate large environmental concerns. A cyclodextrin (CD) mediated Fenton remediation of TNT contaminated water and sand (soil analogy) is presented. Kinetic studies were performed to elucidate the role of cyclodextrin in Fenton remediation of TNT contaminated water. The rate and extent …
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Preparation of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles for Pharmaceutical Applications
… methods. Modification of the carbohydrate cyclodextrin increases the ability to encapsulate hydrophobic pharmaceutical molecules by forming a carrier with a hydrophobic core and hydrophilic exterior. Guest molecules are commonly added to these inclusion complexes in order to add stability …
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Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes
… generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties.
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Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol
The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous …
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Improved Properties of Natamycin Upon Formation of Cyclodextrin Inclusion Complexes
… were formed with β-, hydroxypropyl β-, and γ- cyclodextrins (CDs) which allowed large increases in aqueous solubility without the use of organic co-solvents or surfactants. The water solubility of natamycin was increased 16-fold, 73- fold, and 152-fold with β-CD, γ-CD, and hydroxypropyl β-CD, …
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Targeted Drug Delivery with Cyclodextrin-based Nanocarriers and Focused Ultrasound Triggering
… / cellular drug uptake.<br/>Methods: A novel ?-cyclodextrin (?-CD) based carrier for encapsulation of doxorubicin (DOX) was synthesised and fully characterised. The encapsulation efficiency was assessed under various temperatures and pH levels by both chemical analysis and in vitro human cancer …
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Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene
… of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl …
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Crystal isostructurality and X-ray diffraction studies of cyclodextrin inclusion compounds
… organic inclusion complexes of all three natural cyclodextrins (a-,
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