Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol

The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2004

Author dc:creator

• Oliver, Clive Lloyd

Advisors dc:contributor.advisor

• Caira, Mino R
• Bourne, Susan

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6356

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6356