{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/6356"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/6356","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol","abstract":"The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study.","abstract_html":"The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study.","abstract_has_math":false,"creators":["Oliver, Clive Lloyd"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Caira, Mino R","Bourne, Susan"],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004","date_published":"2004","updated_at":"2026-07-22T22:22:55Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/6356","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Caira, Mino R","Bourne, Susan"]},{"key":"dc:creator","label":"Author","values":["Oliver, Clive Lloyd"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-08-13T14:29:25Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-08-13T14:29:25Z"]},{"key":"dc:date.issued","label":"Date","values":["2004"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/6356"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 199-207)."]},{"key":"dc:description.abstract","label":"Abstract","values":["The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study."]},{"key":"dc:title","label":"Title","values":["Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol"]}]}],"canonical_facts":{"dc:contributor.advisor":["Caira, Mino R","Bourne, Susan"],"dc:creator":["Oliver, Clive Lloyd"],"dc:date.accessioned":["2014-08-13T14:29:25Z"],"dc:date.available":["2014-08-13T14:29:25Z"],"dc:date.issued":["2004"],"dc:description":["Includes bibliographical references (leaves 199-207)."],"dc:description.abstract":["The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study."],"dc:identifier.uri":["http://hdl.handle.net/11427/6356"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:22:55Z"}