Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes

Non-steroidal anti-inflammatory drugs (NSAIDs) are used for the prevention of pain and inflammation. These symptoms are brought about by the action of biochemicals such as prostoglandins, which result from the conversion of a fatty acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, thereby exerting their analgesic effect. Since, however, the solubility and bioavailability of NSAIDs are generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2004

Author dc:creator

• Dean, Pamela Mary

Advisor dc:contributor.advisor

• Caira, Mino R

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6303

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6303