Investigation of Adiposity Phenotypes in AA Associated With GALNT10 & Related Pathway Genes

The overall goal of this project is to verify previous findings in the GALNT10 region and to expand our knowledge of this locus via genomic association studies in obesity-related traits, comparison to expression quantitative trait loci (eQTL) data, and a mouse knockout model, in addition to furthering our knowledge of genes in the pathway in which GALNT10 acts. Previously, genome-wide association studies in African Americans (AA) have identified common variants upstream of GALNT10 locus for association with body mass index (BMI). These studies encompassed a small number of variants upstream of GALNT10 that were common, noncoding variants, as is typically seen in GWAS studies.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2018

Author dc:creator

• Stromberg, Mary

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/93050

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/93050