THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES

Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2016

Author dc:creator

• Ortega, Victor Enrique

• asthma

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/62631

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/62631