{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/62631"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/62631","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES","abstract":"Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD.","abstract_html":"Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency &lt;0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD.","abstract_has_math":false,"creators":["Ortega, Victor Enrique"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016","date_published":"2016","updated_at":"2026-07-27T22:02:05Z","subjects":["asthma"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/62631","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ortega, Victor Enrique"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-08-25T08:35:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2021-08-18T08:30:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2016"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["asthma"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/62631"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD."]},{"key":"dc:title","label":"Title","values":["THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES"]}]}],"canonical_facts":{"dc:creator":["Ortega, Victor Enrique"],"dc:date.accessioned":["2016-08-25T08:35:19Z"],"dc:date.available":["2021-08-18T08:30:13Z"],"dc:date.issued":["2016"],"dc:description.abstract":["Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD."],"dc:identifier.uri":["http://hdl.handle.net/10339/62631"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["asthma"],"dc:title":["THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:05Z"}