Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration

There are currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and cognitive function may provide valuable information to aid in pharmacotherapy development. The present studies utilized female monkeys housed in groups of four to examine the interactions of social rank and hormone concentrations on vulnerability to cocaine reinforcement and cognitive function. The overarching goal was to characterize how estradiol (E2) and progesterone (P4) concentrations influence cognitive performance, eventual social rank and vulnerability to cocaine self-administration (SA). We also examined how social rank altered these and additional hormonal measures.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2015

Author dc:creator

• Kromrey, Sarah Allyson

• cocaine

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/57103

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/57103