Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 305 for “"cocaine"”.
-
Circadian Influences in Cocaine Reinforcement
… associated with circadian influences in cocaine reinforcement. The central themes that run throughout are 24-hour cocaine self-administration and the impact of time-of-day and brain cocaine levels on cocaine taking.
-
Behavioral Models of Cocaine Use Disorder
The complex set of symptoms associated with substance use disorder has made creating animal models with high predictive validity difficult. One tactic to help translate results from animal studies to humans is to separate the symptoms of substance use disorder into two broad categories of …
-
Effects of cocaine on male fertility
… was to demonstrate the adverse effects of cocaine on male fertility and to identify the mechanisms of action of cocaine on testicular function. Materials and Methods: Peripubertal male rats were given cocaine hydrochloride (15 mg./kg body weight, corresponding to an average single dose for …
-
Prenatal Cocaine Exposure and Cardiac Programming
… of ischemia heart disease in later adult life. Cocaine abuse during pregnancy has been shown to cause abnormities in the heart during fetal and postnatal development, but mechanisms underlying the detrimental effects of cocaine on the developing heart are not fully understood. The central …
-
COGNITIVE FUNCTION IN AGING COCAINE SMOKERS
… becoming more prevalent in the aging population. Cocaine, specifically, is a major concern as it is the most commonly reported illegal drug associated with emergency room visits among older adults. The combined effects of aging and long-term cocaine use may significantly impact cognitive function …
-
Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation
Maternal cocaine addiction is a significant public health problem yet
-
Cocaine Use Disorder: Anhedonia and Emotional Flattening
… pleasure, is common among individuals with cocaine use disorder (CUD) and may contribute to poor treatment outcomes. This blunted emotional experience may extend beyond diminished positive affect to include reduced sensitivity to negative emotions, suggesting a broader emotional flattening. …
-
The immunodetection of cocaine for forensic applications.
Cocaine on banknotes can be indicative of drug trade; analytical methods which can distinguish ‘drug money’ from contaminated banknotes in general circulation are crucial in providing incriminating evidence. The development and application of two analytical methods for the detection of cocaine on …
-
Evaluation of agonist pharmacotherapy for cocaine dependence: effects of continuous d-amphetamine treatment on cocaine self-administration in rats
Cocaine dependence is a chronic disease which causes an immeasurable amount of detriment at both individual and societal levels. Although several promising pharmacological treatments are under development, the process of bringing an investigational drug to market requires substantial investments of …
-
The Role of Adult Neurogenesis in Cocaine Addiction
… drug-taking. I first examined effects of chronic cocaine self-administration and withdrawal on the different stages of neurogenesis. I found an early deficit in proliferation of neural progenitors, as well as a 4 week delayed increase in doublecortin-positive (DCX+) immature neurons which were …
-
Role of BDNF-TrkB Signaling in Cocaine Addiction
Cocaine addiction results in neuroadaptations and drug-induced neuroplasticity that promote changes in protein expression and neuron morphology. Cocaine-induced increases in dopamine ultimately alter dopamine signaling in brain regions modulating reward and motivation, specifically the nucleus …
-
Cocaine Dependence: The Role of Serotonin Genes In
… studies have shown that behavioral responses to cocaine-related cues are altered by serotonergic medications. The effects of pharmacological agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the …
-
Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations
Cocaine addiction is a chronic, relapsing disease affecting millions of Americans, and differences between individuals modulate the progression from cocaine use to addiction. Learned associations between cocaine and environmental stimuli develop in the subset of patients who become addicted, and …
-
Drugs in oral fluid – an evaluation of the release of cocaine and cocaine derivatives from oral drug depots into oral fluid.
… the existing knowledge on the release of cocaine and cocaine related compounds from oral drug depots into OF and evaluating alternative techniques for the detection of drugs in OF and biological tissues. To accomplish this, the kinetics of release of cocaine and cocaine derivatives were …
-
The Cocaine-Wildlife Connection: Crime Convergence in Central America
… trade in Central America and its connections to cocaine trafficking in protected areas by conducting a comparative study of Costa Rica and Guatemala. Recent scholarship on conservation crime suggests that illicit markets and trade networks intersect in Central American biodiversity hotspots, …
-
Investigations of the neurobiological and behavioural actions of cocaine
… once considered a benign recreational stimulant, cocaine is now recognized to possess substantial abuse potential with considerable medical and social consequences. Accordingly, these experiments examined the behavioural and neurobiological effects of cocaine in the rat. The behavioural and …
-
Essays on the economics of cocaine production in Colombia
Thesis (Ph. D.)--Michigan State University. Economics, 2010
-
The Educational Implications of Cocaine-Exposed Hearing-Impaired Children
… effects and possible educational implications cocaine exposure in utero has on a hearing-impaired child. A 3 and 1/2 year old child (D.A.) identified as both cocaine-exposed and hearing-impaired served as the subject for this study. Her behaviors were compared with characteristics …
-
Exploring the Feasibility of an Anti-Idiotypic Cocaine Vaccine
Cocaine addiction is a major public health problem for which there are no proven psychotherapies or pharmacotherapies. Upon entry into the body, cocaine rapidly partitions to the brain. A possible means of negating the pharmacological activity of cocaine would be to interrupt the delivery of the …
-
Cocaine Use Modulates Neural Prediction Error During Aversive Learning
Cocaine use has contributed to 5 million individuals falling into the cycle of addiction. Prior research in cocaine dependence mainly focused on rewards. Losses also play a critical role in cocaine dependence as dependent individuals fail to avoid social, health, and economic losses even when they …
Page 1 of 16