Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"self-administration"”.
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Achieving pharmacologically relevant IV alcohol self-administration in the rat
… of alcohol abuse and dependence. Intravenous self-administration of ethanol allows for controlled and precise dosing, bypasses first order absorption kinetics allowing for a faster onset of pharmacologic effects, and eliminates the confounding “non-pharmacological” effects associated with oral …
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UNIQUE PHARMACODYNAMIC PROFILE OF METHYLPHENIDATE: SELF-ADMINISTRATION-INDUCED DOPAMINE SYSTEM ALTERATIONS
… and the compensatory alterations associated with self-administration of the compound. This work has elucidated the neurochemical consequences of MPH self-administration, whereby MPH administration by a number of paradigms results in consistent neurochemical adaptations characterized by increased …
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The effects of chronic ethanol self-administration on the serotonin system in monkeys
Serotonin plays an important role in mediating the effects of alcohol, but current serotonergic pharmacotherapies for alcoholism have had only modest success. Serotonin's effects on drinking are mediated at least in part by modulating neuroplasticity in the hippocampal formation. The hippocampal …
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THE GROUP II METABOTROPIC GLUTAMATE AGONIST, LY379268, DECREASES METHAMPHETAMINE SELF-ADMINISTRATION IN RATS
… II mGluR agonist (LY379268) in reducing METH self-administration in a well-established animal model of drug abuse. <italic>Methods</italic>: The effects of LY379268 on progressive ratio breakpoints for METH or food were assessed. Rats were trained to self-administer either METH or a control …
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Locomotor activity does not predict individual differences in morphine self-administration in rats
… differences in acquisition of i.v. morphine self-administration (SA) in rats. A secondary goal was to evaluate the relationship between activity and elasticity of demand (reinforcing efficacy) for morphine measured using a behavioral economic approach. Following an initial locomotor activity …
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Contributions of early life adversity, sex, and traits towards compulsive opioid self-administration
… assessment, I observed the rats’ propensity to self-administer the opiate remifentanil. I then killed a subset of rats and quantified DA receptor mRNA in the mPFC. ELA decreased impulsivity and decreased the rate of acquisition of opiate self-administration in male rats only. Compared to males, …
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Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball
… reuptake kinetic parameters following acute administration of cocaine, heroin and speedball in drug-naïve rats, as well in rats with chronic self-administration (SA) history of cocaine, heroin and speedball. Together, the results have shown that speedball combinations likely induced DA …
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Parsing Distinct Aspects of the Addiction Process Using Cocaine Self-Administration, Behavioral Economics, Neuropharmacology and Neurochemistry
… behavioral economic analyses on cocaine self-administration data. Using behavioral economic theory, changes in cocaine intake can be investigated by studying changes in consumption when the unit-price of cocaine is relatively cheap; changes in the time and energy devoted to obtain cocaine …
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SEX DIFFERENCES IN THE ROLE OF PKMζ IN DRUG SELF-ADMINISTRATION AND PREFRONTAL CORTEX SYNAPTIC PLASTICITY
Neuroadaptations associated with addiction are hypothesized to involve the same glutamatergic cellular mechanisms that underlie learning and memory. Further, there are clear sex differences in both rates of diagnosis and symptom severity in substance use disorder which may result from sexually …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… to glutamate receptors, SAPAPs, and affects drug self-administration. Taking all the previously discussed research studies into consideration, we hypothesized that low-dose cocaine self-administration would yield a significant elevation in drug seeking behavior for psychostimulant sensitized …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… glutamatergic system during chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, and after extinction. In the initial study, after 18 days of nicotine SA, in the medial prefrontal cortex (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were …
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The Effects of Early-Life Lead Exposure on Adult Delta9-Tetrahydrocannabinol Sensitivity, Self-administration, and Tolerance
… to answer whether Pb exposure affects edible THC self-administration and the development of THC tolerance (also measured by the tetrad). It was hypothesized that Pb exposure would decrease THC sensitivity (Aim 1), would enhance THC self-administration (Aim 2), enhance the development of THC …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… compounds. Studying nonhuman primates in drug self-administration is most predictive of the clinical condition in humans, thus, provides important clinically translational insight into medications development for treatment of substance abuse. Most drugs of abuse alter dopamine (DA) …
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Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation
Maternal cocaine addiction is a significant public health problem yet
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Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration
… social rank and vulnerability to cocaine self-administration (SA). We also examined how social rank altered these and additional hormonal measures.
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
… (NR) and mother-reared rhesus monkeys induced to self-administer EtOH or control solution for over 12 months. Subjects underwent endocrine challenges to probe the HPA axis before and after drinking. Brains were processed for in vitro receptor autoradiography using [125I] Sauvagine and appropriate …
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Cocaine self-administration in rhesus monkeys: effects on neurobiology and cognition and evaluation of cognitive enhancement for addiction treatment
No effective drug treatments for cocaine dependence exist, although combined behavioral and pharmacological interventions, reviewed in Chapter I, may lead to better treatment outcomes. The goal of the current research is to characterize neurobiological and cognitive deficits associated with cocaine …
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Evaluation of agonist pharmacotherapy for cocaine dependence: effects of continuous d-amphetamine treatment on cocaine self-administration in rats
… Thus far, studies have shown that the route of administration and treatment regimen greatly influence the therapeutic effectiveness of d-amphetamine in that continuous, but not acute, administration of d-amphetamine decreases the reinforcing effects of cocaine. The studies presented in Chapters …
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