Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers

In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2014

Author dc:creator

• Jordan, Jennifer Hawthorne

• Cardiotoxicity

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/47458

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/47458